Essentials of Thyroid Cancer
Buku ini diterbitkan tahun 2005 oleh Springer Science+Business Media, Inc. New York. Adalah buku edisi Pertama.
Judul: Essentials of Thyroid Cancer
Oleh: Robert J. Amdur, MD, et al (Editor)
Penerbit: Springer Science+Business Media, Inc.
Tahun: 2006
Jumlah Halaman: 432 hal.
Editor:
ROBERT J. AMDUR, MD
Professor, Department of Radiation Oncology
University of Florida College of Medicine
Gainesville, Florida USA
ERNEST L. MAZZAFERRI, MD, MACP
Professor, Department of Medicine
University of Florida College of Medicine
Gainesville, Florida USA
Emeritus Professor and Chairman of Internal Medicine
Ohio State University
Columbus, Ohio USA
Lingkup Pembahasan:
Pembahaan dalam buku ini meliputi Diagnosis dan Pencitraan Kanker Tiroid, Insiden dan Prognosis perbedaan Kanker Tiroid, Terapi Bedah dari Perbedaan Kanker Tiroid, Terapi Media dari Perbedaan Kanker Tiroid, Tindak Lanjut Surat Perjanjian dan Pengobatan Rekuren atau metastasis Perbedaan Kanker Tiroid, Perbedaan Kanker Tiroid selama Kehamilan, dalam Tiroglosus DUCT dan Subtipe Histologis tidak menguntung DTC, Meduler Kanker Tiroid, Eskternal Beam Terapi Radiasi, Referensi untuk Dokter dan Pasien.
Daftar Isi:
Contributing Authors xiii
Acknowledgement xv
Preface xvii
PART 1. INTRODUCTION 1
1.1. Basic Thyroid Anatomy 3
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
1.2. Thyroid and Parathyroid Physiology 7
ERNEST L. MAZZAFERRI, MD, MACP AND ROBERT J. AMDUR, MD
1.3. Pathology and Classification of Thyroid Carcinoma 19
HEATHER M. BROWN, MD, ROBERT J. AMDUR, MD AND ERNEST L.
MAZZAFERRI, MD, MACP
1.4. The American Joint Committee on Cancer System of Staging Thyroid Cancer 33
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
PART 2. DIAGNOSIS AND IMAGING OF THYROID CANCER 37
2.1. The Diagnosis of Thyroid Cancer 39
ERNEST L. MAZZAFERRI, MD, MACP
2.2. Definitions: Thyroid Uptake Measurement, Thyroid Scan, and Whole Body Scan 49
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
2.3. Thyroid Stunning 55
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
2.4. The Role of a Diagnostic Radioiodine Whole Body Scan (DxWBS) 61
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
2.5. The Value of a Post-Treatment Whole Body Scan 65
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
2.6. Examples of Radioiodine Whole Body Scans 69
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
2.7. Computerized Tomography (CT) and Magnetic Resonance (MR) Imaging of Thyroid
Cancer 91
ILLONA M. SCHMALLFUSS, MD, ROBERT J. AMDUR, MD, DOUGLAS B.
VILLARET, MD AND ERNEST L. MAZZAFERRI, MD, MACP
2.8. Positron Emission Tomography (PET) of Thyroid Cancer 95
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
2.9. Neck Ultrasonography in Patients with Thyroid Cancer 101
ERNEST L. MAZZAFERRI, MD, MACP
PART 3. INCIDENCE AND PROGNOSIS OF DIFFERENTIATED THYROID CANCER 121
3.1. Incidence, Prevalence, Recurrence, and Mortality of Differentiated Thyroid
Cancer 123
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
3.2. Factors That Predict Cancer Recurrence and Death from Differentiated Thyroid
Cancer 131
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
PART 4. SURGICAL THERAPY OF DIFFERENTIATED THYROID CANCER 141
4.1. A Total Thyroidectomy Rarely Removes All Thyroid Tissue 143
DOUGLAS B. VILLARET, MD, ROBERT J. AMDUR, MD AND ERNEST L.
MAZZAFERRI, MD, MACP
4.2. Neck Dissections to Remove Malignant Lymph Nodes 147
DOUGLAS B. VILLARET, MD, ROBERT J. AMDUR, MD AND ERNEST L.
MAZZAFERRI, MD, MACP
4.3. Potential Complications of Thyroid Cancer Surgery 153
DOUGLAS B. VILLARET, MD, ROBERT J. AMDUR, MD AND ERNEST L.
MAZZAFERRI, MD, MACP
PART 5. MEDICAL THERAPY OF DIFFERENTIATED THYROID CANCER 161
A.BACKGROUND INFORMATION AND PROCESS ADMINISTRATION 163
5A.1. Half-life and Emission Products of I-131 165
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
5A.2. Choosing the Activity of I-131 for Therapy 169
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
5A.3. Requirements for Outpatient Release Following I-131 Therapy 177
ROBERT J. AMDUR, MD, GEORGE SNYDER, AND ERNEST L. MAZZAFERRI,
MD, MACP
5A.4. A Checklist of Things to do at the Clinic Visit Prior to I-131 Therapy 183
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
5A.5. A Checklist of Things to do on the Day of I-131 Administration 189
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
5A.6. Documents That Facilitate I-131 Scheduling and Patient Education 193
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
B. PREPARING PATIENTS FOR I-131 THERAPY 203
5B.1. The Low-Iodine Diet 205
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
5B.2. Intravenous Iodinated Contrast Effects Iodine Uptake for Months 211
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
5B.3. Measuring Urinary Iodine (UI) 215
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
5B.4. Using Lithium Carbonate to Increase the Effectiveness of I-131 221
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
5B.5. Thyroid Hormone Withdrawal to Elevate TSH 229
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
5B.6. Recombinant Human TSH: Background Information and Standard Protocol 233
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
5B.7. Using rhTSH prior to I-131 Therapy 239
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
C. THYROID REMNANT ABLATION 247
5C.1. I-131 Therapy in a Patient with a Small Thyroid Remnant 249
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
5C.2. I-131 Therapy in a Patient with a Large Thyroid Remnant 257
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
D. SUPPRESSION OF TSH AND THE POTENTIAL TOXICITY OF I-131 THERAPY 261
5D.1. Effects of Suppressing TSH on Tumor Growth and Recurrence 263
ERNEST L. MAZZAFERRI, MD, MACP
5D.2. Potential Side Effects and Complications of I-131 Therapy 267
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
5D.3. Management of Xerostomia, Taste Impairment and Dental Prophlaxis 281
ROBERT J. AMDUR, MD, PAMELA L. SANDOW, DMD, WILLIAM M.
MENDENHALL, MD, AND ERNEST L. MAZZAFERRI, MD, MACP
PART 6. FOLLOW-UP PROTOCOL AND TREATMENT OF RECURRENT OR METASTATIC DIFFERENTIATED THYROID CANCER 285
6.1. An Overview of Follow-up of Differentiated Thyroid Cancer 287
ERNEST L. MAZZAFERRI, MD, MACP
6.2. Follow-up of Differentiated Thyroid Cancer Using Serum Thyroglobulin
Measurements 295
ERNEST L. MAZZAFERRI, MD, MACP
6.3. Overview of Management of Differentiated Thyroid Carcinoma in Patients with
Negative Whole Body Radioiodine Scans and Elevated Serum Thyroglobulin
Levels 303
ERNEST L. MAZZAFERRI, MD, MACP
6.4. Treatment Guidelines When the Only Evidence of Disease is an Elevated Serum
Thyroglobulin Level 313
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
6.5. Treatment of Residual Differentiated Thyroid Cancer in the Neck and
Mediastinum 317
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
6.6. Treatment of Lung Metastases from Differentiated Thyroid Cancer 319
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
6.7. Treatment of Bone Metastases from Differentiated Thyroid Cancer 329
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
6.8. Treatment of Spinal Cord Compression from Metastatic Thyroid Cancer 337
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
6.9. Treatment of Brain Metastasis from Differentiated Thyroid Cancer 341
ROBERT J. AMDUR, MD, ILLONA M. SCHMALFUSS, AND ERNEST L.
MAZZAFERRI, MD, MACP
PART 7. DIFFERENTIATED THYROID CANCER DURING PREGNANCY, IN A THYROGLOSSAL DUCT, AND UNFAVORABLE HISTOLOGIC SUBTYPES OF DTC 345
7.1. Management of Differentiated Thyroid Cancer During Pregnancy 347
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
7.2. Thyroid Cancer Originating in a Thyroglossal Duct Remnant 351
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
7.3. Tall and Collumnar Variants of Papillary Carcinoma 355
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
7.4. Diffuse Sclerosing Variant of Papillary Carcinoma 359
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
7.5. H¨urthle Cell Carcinoma 361
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
7.6. Insular and Other Poorly Differentiated Thyroid Carcinomas 365
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
7.7. Anaplastic Carcinoma 369
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
PART 8. MEDULLARY THYROID CANCER 375
8.1. Diagnosis and Management of Medullary Thyroid Carcinoma 377
ERNEST L. MAZZAFERRI, MD, MACP AND NICOLE A. MASSOLL, MD
PART 9. EXTERNAL BEAM RADIATION THERAPY 403
9.1. External Beam Radiotherapy Dose Schedules 405
ROBERT J. AMDUR, MD, SIYONG KIM, PhD, JONATHAN GANG LI, PhD, CHIRAY LIU, PhD, WILLIAM M. MENDENHALL, MD, AND ERNEST L.
MAZZAFERRI, MD, MACP
9.2. Indications for External Beam Radiation Therapy for Differentiated Thyroid
Cancer 407
ROBERT J. AMDUR, MD, WILLIAM M. MENDENHALL, MD, AND
ERNEST L. MAZZAFERRI, MD, MACP
9.3. Sequencing of I-131 and External Beam Radiation Therapy for Differentiated
Thyroid Cancer 413
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
9.4. Indications for EBRT for Medullary and Anaplastic Thyroid Carcinoma 415
ROBERT J. AMDUR, MD, WILLIAM M. MENDENHALL, MD, AND
ERNEST L. MAZZAFERRI, MD, MACP
9.5. Conventional Radiotherapy Technique for Treating Thyroid Cancer 419
ROBERT J. AMDUR, MD, SIYONG KIM, PhD, JONATHAN GANG LI, PhD, CHIRAY
LIU, PhD, WILLIAM M. MENDENHALL, MD, AND ERNEST L.
MAZZAFERRI, MD, MACP
9.6. Intensity Modulated Radiation Therapy for Thyroid Cancer 425
ROBERT J. AMDUR, MD, SIYONG KIM, PhD, JONATHAN GANG LI, PhD, CHIRAY
LIU, PhD, WILLIAM M. MENDENHALL, MD, AND ERNEST L.
MAZZAFERRI, MD, MACP
9.7. Drawing Target Volumes for Intensity Modulated Radiation Therapy for
Thyroid Cancer 433
ROBERT J. AMDUR, MD, JONATHAN GANG LI, PhD, SIYONG KIM, PhD,
CHIRAY LIU, PhD, WILLIAM M. MENDENHALL, MD, AND ERNEST L.
MAZZAFERRI, MD, MACP
9.8. Potential Toxicity of External Beam Radiotherapy for Thyroid Cancer 439
ROBERT J. AMDUR, MD, WILLIAM M. MENDENHALL, MD, AND
ERNEST L. MAZZAFERRI, MD, MACP
PART 10. REFERENCE INFORMATION FOR PHYSICIANS AND PATIENTS 443
10.1. Resource Websites 445
ROBERT J. AMDUR, MD AND ERNEST L. MAZZAFERRI, MD, MACP
Index 447
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