Harrison’s Principles of Internal Medicine 16th Edition
Buku ini diterbitkan tahun 2005 McGraw-Hill Companies Inc. adalah buku Edsi Enambelas.
Judul: Harrison’s Principles of Internal Medicine 16th Edition
Oleh: Denis L. Kasper, MD, et al (Editor)
Penerbit: McGraw-Hill Companies Inc.
Tahun: 2005
Jumlah Halaman: 2783 hal.
Editor:
DENNIS L. KASPER, MD
William Ellery Channing Professor of Medicine,
Professor of Microbiology and Molecular Genetics,
Harvard Medical School; Director, Channing
Laboratory, Department of Medicine, Brigham and
Women’s Hospital, Boston
ANTHONY S. FAUCI, MD
Chief, Laboratory of Immunoregulation; Director,
National Institute of Allergy and Infectious Diseases,
National Institutes of Health, Bethesda
DAN L. LONGO, MD
Scientific Director, National Institute on Aging,
National Institutes of Health,
Bethesda and Baltimore
EUGENE BRAUNWALD, MD
Distinguished Hersey Professor of Medicine,
Harvard Medical School; Chairman, TIMI Study Group,
Brigham and Women’s Hospital, Boston
STEPHEN L. HAUSER, MD
Robert A. Fishman Distinguished Professor and Chairman,
Department of Neurology,
University of California San Francisco, San Francisco
J. LARRY JAMESON, MD, PHD
Irving S. Cutter Professor and Chairman,
Department of Medicine,
Northwestern University Feinberg School of Medicine;
Physician-in-Chief, Northwestern
Memorial Hospital, Chicago
Lingkup Pembahasan:
Buku ini bukan hanya membantu siswa yang membutuhkan sumber pengetahuan dasar tentang penyakit dalam, tapi juga untuk praktisi yang membutuhkan informasi jelas, ringkas, dan distilasi seimbang terbaik yang menjadi dasar sehari-hari untuk menentukan keputusan klinis. Buku ini terdiri tas Enam Belas Bagian Utama.
Bagian Satu, "Pengantar Clinical Medicine” menyediakan informasi praktis tentang pendekatan skrining bahwa setiap internis harus mempertimbangkan untuk pemeliharaan kesehatan rutin. Bab ini membahas prinsip-prinsip dan pedoman yang digunakan dalam skrining untuk kondisi umum seperti kanker, hipertensi, lipid gangguan, dan osteoporosis. Di samping itu juga mengemukakan pendekatan pragmatis untuk evaluasi medis pasien yang akan menjalani prosedur bedah. Mengingat pertumbuhan gerakan hospice dan meningkatnya kesadaran akan isu-fisik sensitif, mental, sosial, dan eksistensial-yang mengelilingi end-of-hidup perawatan, juga tentang topik yang kompleks ini memberikan wawasan, informasi, dan bimbingan praktisi berurusan dengan pasien sekarat dan keluarga mereka. Juga termasuk
topic tentang kesehatan perempuan mengemukakan gambaran luas dari pendekatan untuk gangguan yang mempengaruhi perempuan secara tidak proporsional.
Bagian Kedua, "Kardinal Manifestasi dan Presentasi Penyakit," pengenalan yang komprehensif untuk pengobatan klinis serta panduan praktis untuk perawatan pasien dengan manifestasi tersebut. Masing masing bagian berfokus pada kelompok tertentu dari gangguan, memeriksa konsep patofisiologi dan diagnosis diferensial yang harus diperhatikan dalam merawat pasien dengan presentasi klinis yang umum. Bagian ini juga mengemukakan Gejala utama ditinjau dan berkorelasi dengan penyakit negara tertentu, dan pendekatan klinis untuk pasien. Bagian ini termasuk juga mengemukakan tentang disfungsi seksual baik pada pria maupun wanita.
Bagian Ketiga, "Genetika dan Penyakit," mengemukakan tentang praktek klinis, di mana informasi genetik sangat deras. Bagian ini juga membahas masalah sel induk dan transfer gen dalam kedokteran klinis dibahas tepat waktu dan kontroversial, mendefinisikan berbagai jenis sel induk dan mendiskusikan aplikasi klinis potensi mereka.
Bagian Keempat, "Nutrisi," mencakup pertimbangan gizi yang berhubungan dengan kedokteran klinis. Area fokus meliputi penilaian gizi dan diet, kebutuhan gizi, kekurangan gizi protein-energi, gangguan makan, obesitas, dan terapi nutrisi enteral dan parenteral.
Inti dari Harrison mencakup gangguan sistem organ dan terkandung di Bagian Limasampai Enam Belas.
Bagian ini termasuk uraian ringkas tentang patofisiologi penyakit yang melibatkan sistem organ utama serta penyakit menular, dengan penekanan pada manifestasi klinis, prosedur diagnostik, diagnosis, dan strategi pengobatan dan pedoman.
Bagian Kelima, "Onkologi dan Hematologi," mencakup empat meliputi peningkatan proporsi pasien yang mengembangkan kanker yang sedang disembuhkan. Hal ini penting untuk mendeteksi konsekuensi akhir sedini mungkin dalam sejarah alam mereka untuk mengoptimalkan hasil. Bab tentang
konsekuensi akhir kanker dan pengobatannya membantu dokter Berikut pasien tersebut untuk mengetahui apa yang harus dicari selain kambuhnya kanker. Kemajuan dalam pengelolaan banyak kanker disorot-misalnya, dampak dramatis imatinib mesylate (Gleevec) pada leukemia myeloid kronis dan gastrointestinal. Tumor sel stroma dan peran rituximab dalam pengelolaan limfoma dan penyakit autoimun. Di samping itu juga mengemukakan bab yang menggambarkan prinsip-prinsip terapi radiasi dan merupakan bagian pelengkap untuk bab penulis ini pada bioterorisme radiasi di Bagian Ketujuh’ Bagian hematologi fitur Klasifikasi baru Organisasi Kesehatan Dunia limfoid dan myeloid neoplasma. Bagian Keenam, "Penyakit Menular," merangkum informasi terbaru tentang patologi, genetika, dan epidemiologi sambil memfokuskan tajam pada kebutuhan dokter yang harus secara akurat mendiagnosa dan mengobati infeksi di bawah tekanan waktu dan kendala biaya. Secara khusus, inklusi puluhan ilustrasi penuh warna disediakan dan informasi yang mudah diakses untuk membantu dokter. Rekomendasi spesifik disediakan untuk rejimen terapi, termasuk obat pilihan, dosis, durasi, dan alternatif. Saat ini trend dalam antimikroba resistensi disajikan dan dipertimbangkan secara jelas dampak pada pilihan terapi. Di samping itu bagian ini juga mengemukakan informasi kunci pada pengelolaan masalah klinis yang kompleks yang diangkat oleh Clostridium difficile terkait penyakit, termasuk kolitis pseudomembran. Lemajuan terbaru dalam pengelolaan penyakit disebabkan oleh stafilokokus dan nontuberculous mycobacteria, gastroenteritis virus, dan brucellosis. Termasuk juga bab yang membahas infeksi virus pernapasan umum mencakup cakupan menyeluruh sindrom pernapasan akut parah (SARS). Bab yang berfokus pada klinis pragmatis dalam kombinasi dengan pendekatan yang komprehensif dan analitis terhadap patogenesis penyakit HIV telah memungkinkan penggunaannya sebagai satu-satunya yang referensi lengkap tentang HIV / AIDS di sekolah kedokteran.
Bagian Ketujuh, "bioterorisme dan Kedokteran Klinis," terdiri dari bahan tiga bidang bioterorisme: mikroba, kimia, dan radiasi. Termasuk grafik yang mudah dibaca, meja, dan algoritma; untuk memberikan pemahaman tentang patogenesis, diagnosis, pengobatan, dan prognosis dari penyakit tersebut.
Bagian Kedelapan, "Gangguan pada Sistem Kardiovaskular," mencakup topik-topik penting secara klinis angina tidak stabil dan non-ST-segmen elevasi infark miokard; intervensi koroner perkutan untuk ST-segmen elevasi miokard infark serta obat-obatan baru dan perangkat untuk pengobatan gagal jantung.
Bagian Kesembilan, "Gangguan Sistem Pernapasan, " berfokus pada seleksi pasien untuk intervensi Termasuk topik yang luas tentang pneumonia dan abses paru, memberikan fokus dan perspektif klinis untuk membantu pembaca memahami isu sentral terlibat dalam diagnosis dan manajemen dari masyarakat dan penyakit nosokomial.
Bagian Kesepuluh, "Critical Care Medicine," Khusus untuk penyediaan pelayanan yang optimal dalam hal ini pengaturan medis semakin penting. Juga mengemukakan tentang topik tiga bidang utama: perawatan pernapasan kritis, shock dan serangan jantung, serta perawatan kritis neurologis. Pada bagian ini juga mengemukakan pendekatan kepada pasien dan prinsip utama yang mendasari perawatan kritis.
Bagian Sebelas, "Gangguan Ginjal dan Saluran Kemih," memberikan gambaran yang menyeluruh dari gangguan saluran kencing yang merupakan penyakit dalam.
Bagian Dua Belas, "Gangguan Sistem Gastrointestinal," mengemukakan bab tentang Pendekatan kepada pasien dengan penyakit gastrointestinal, bab tentang divertikular dan penyakit pembuluh darah dari usus, dan bab-bab pada berbagai kategori hepatitis virus untuk mencerminkan kemajuan terobosan dalam pengobatan.
Bagian Tiga belas, "Gangguan pada sistem kekebalan tubuh, Tissue ikat, dan sendi, " memberikan pengenalan sistem kekebalan tubuh. Bab ini juga menggabungkan deskripsi mendalam dan analisis
prinsip-prinsip imunologi dasar dengan aliran yang mudah ke aplikasi dari prinsip-prinsip ini kepada negara-negara penyakit klinis. Deskripsi hubungan bawaan kekebalan adaptif adalah model untuk memahami seluk-beluk sistem kekebalan tubuh manusia. Bagian Empat belas, "Endokrinologi dan Metabolisme," meliputi enam bab dengan penulis baru serta bab baru tepat waktu pada perimenopause transisi dan terapi penggantian hormon. Perempuan Health Initiative yang tiba-tiba menunjukkan peningkatan risiko penyakit kardiovaskular pada wanita yang menerima pengobatan estrogen. Bagian ini juga menyediakan algoritma praktis untuk pengelolaan pasien selama masa transisi.
Di samping itu juga mengemukakan gangguan diferensiasi seksual menyoroti wawasan baru yang berasal dari penjelasan dasar genetik penentuan seks. Bagian ini juga membahas tulang dan mineral
metabolisme meletakkan dasar yang luar biasa untuk memahami patofisiologi dan pengobatan berbagai penyakit tulang metabolik. Bab ini menyoroti gangguan metabolisme lipoprotein
dengan fokus yang lebih tajam pada klasifikasi, diagnosis, dan pengobatan gangguan kolesterol dan trigliserida metabolisme, dan menekankan penggunaan statin untuk pengurangan risiko kardiovaskular.
Bagian Lima belas, "Gangguan neurologis," membahas secara komprehensif pada penyakit Alzheimer dan terkait demensia merangkum ledakan baru perihal pengetahuan tentang topik, menyoroti pemahaman baru tentang genetika demensia dan molekul yang memicu mereka serta menyediakan panduan klinis untuk diagnosis, diagnosis banding, dan perawatan terbaru. Di samping itu juga membahas penyakit Parkinson dan temuan genetik dan memberikan pendekatan otoritatif terhadap terapi, termasuk pilihan bedah. Bagian ini membahas juga bab tentang penyakit serebrovaskular, yang menawarkan pendekatan berbasis bukti untuk pengobatan dan pencegahan stroke, pembunuh utama ketiga dunia Barat. Bagian Enam belas "Keracunan, Obat Overdosis, dan Envenomation," berfokus pada topik yang paling relevan dengan penyakit.
Daftar Isi:
Contributors xv
Preface xxv
Part One
INTRODUCTION TO CLINICAL MEDICINE
1 The Practice of Medicine 1
The Editors
2 Decision-Making in Clinical Medicine 6
Daniel B. Mark
3 Principles of Clinical Pharmacology 13
Dan M. Roden
4 Screening and Prevention of Disease 26
Gary J. Martin
5 Women’s Health 28
Andrea Dunaif
6 Medical Disorders During Pregnancy 32
Robert L. Barbieri / John T. Repke
7 Medical Evaluation of the Surgical Patient 38
Gerald W. Smetana
8 GeriatricMedic ine 43
Neil M. Resnick / David Dosa
9 Palliative and End-of-Life Care 53
Ezekiel J. Emanuel / Linda L. Emanuel
10 Complementary and Alternative Medicine 66
Stephen E. Straus
Part Two
CARDINAL MANIFESTATIONS AND PRESENTATION OF DISEASES
SECTION 1 PAIN
11 Pain: Pathophysiology and Management 71
Howard L. Fields / Joseph B. Martin
12 Chest Discomfort and Palpitations 76
Thomas H. Lee
13 Abdominal Pain 82
William Silen
14 Headache 85
Neil H. Raskin
15 Back and Neck Pain 94
John W. Engstrom
SECTION 2 ALTERATIONS IN BODY TEMPERATURE
16 Fever and Hyperthermia 104
Charles A. Dinarello / Jeffrey A. Gelfand
17 Fever and Rash 108
Elaine T. Kaye / Kenneth M. Kaye
18 Fever of Unknown Origin 116
Jeffrey A. Gelfand / Michael V. Callahan
19 Hypothermia and Frostbite 121
Daniel F. Danzl
SECTION 3 NERVOUS SYSTEM DYSFUNCTION
20 Syncope, Faintness, Dizziness, and Vertigo 126
Robert B. Daroff / Mark D. Carlson
21 Weakness, Disorders of Movement, and Imbalance 134
Richard K. Olney
22 Numbness, Tingling, and Sensory Loss 141
Arthur K. Asbury
23 Aphasia, Memory Loss, and Other Focal Cerebral Disorders 145
M.-Marsel Mesulam
24 Sleep Disorders 153
Charles A. Czeisler / John W. Winkelman / Gary S. Richardson
SECTION 4 DISORDERS OF EYES, EARS, NOSE, AND THROAT
25 Disorders of the Eye 162
Jonathan C. Horton
26 Disorders of Smell, Taste, and Hearing 176
Anil K. Lalwani / James B. Snow, Jr.
27 Infections of the Upper Respiratory Tract 185
Michael A. Rubin / Ralph Gonzales / Merle A. Sande
28 Oral Manifestations of Disease 194
Samuel C. Durso
SECTION 5 ALTERATIONS IN CIRCULATORY AND RESPIRATORY FUNCTIONS
29 Dyspnea and Pulmonary Edema 201
Roland H. Ingram, Jr. / Eugene Braunwald
30 Cough and Hemoptysis 205
Steven E. Weinberger
31 Hypoxia and Cyanosis 209
Eugene Braunwald
32 Edema 212
Eugene Braunwald
SECTION 6 ALTERATIONS IN GASTROINTESTINAL FUNCTION
33 Dysphagia 217
Raj K. Goyal
34 Nausea, Vomiting, and Indigestion 219
William L. Hasler
35 Diarrhea and Constipation 224
David A. Ahlquist / Michael Camilleri
36 Weight Loss 233
Carol M. Reife
37 Gastrointestinal Bleeding 235
Loren Laine
38 Jaundice 238
Daniel S. Pratt / Marshall M. Kaplan
39 Abdominal Swelling and Ascites 243
Robert M. Glickman
SECTION 7 ALTERATIONS IN RENAL AND URINARY TRACT FUNCTION
40 Azotemia and Urinary Abnormalities 246
Bradley M. Denker / Barry M. Brenner
41 Fluid and Electrolyte Disturbances 252
Gary G. Singer / Barry M. Brenner
42 Acidosis and Alkalosis 263
Thomas D. DuBose, Jr.
SECTION 8 ALTERATIONS IN SEXUAL FUNCTION AND REPRODUCTION
43 Sexual Dysfunction 271
44 Hirsutism and Virilization 275
David A. Ehrmann
45 Infertility and Fertility Control 279
Janet E. Hall
SECTION 9 ALTERATIONS IN THE SKIN
46 Approach to the Patient with a Skin Disorder 283
Thomas J. Lawley / Kim B. Yancey
47 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders 288
Calvin O. McCall / Thomas J. Lawley
48 Skin Manifestations of Internal Disease 296
Jean L. Bolognia / Irwin M. Braverman
49 Immunologically Mediated Skin Diseases 311
Kim B. Yancey / Thomas J. Lawley
50 Cutaneous Drug Reactions 318
Olivier M. Chosidow / Robert S. Stern / Bruce U. Wintroub
51 Photosensitivity and Other Reactions to Light 324
David R. Bickers
SECTION 10 HEMATOLOGIC ALTERATIONS
52 Anemia and Polycythemia 329
John W. Adamson / Dan L. Longo
53 Bleeding and Thrombosis 337
Robert I. Handin
54 Enlargement of Lymph Nodes and Spleen 343
Patrick H. Henry / Dan L. Longo
55 Disorders of Granulocytes and Monocytes 349
Steven M. Holland / John I. Gallin
Part Three
GENETICS AND DISEASE
56 Principles of Human Genetics 359
J. Larry Jameson / Peter Kopp
57 Chromosome Disorders 379
Terry Hassold / Stuart Schwartz
58 The Practice of Genetics in Clinical Medicine 386
Susan Miesfeldt / J. Larry Jameson
59 Stem Cell and Gene Transfer in Clinical Medicine 392
David Bodine / J. Larry Jameson / Ron McKay
Part Four
NUTRITION
60 Nutritional Requirements and Dietary Assessment 399
Johanna Dwyer
61 Vitamin and Trace Mineral Deficiency and Excess 403
Robert M. Russell
62 Malnutrition and Nutritional Assessment 411
Charles H. Halsted
63 Enteral and Parenteral Nutrition Therapy 415
Lyn Howard
64 Obesity 422
Jeffrey S. Flier / Eleftheria Maratos-Flier
65 Eating Disorders 430
B. Timothy Walsh
Part Five
ONCOLOGY AND HEMATOLOGY
SECTION 1 NEOPLASTIC DISORDERS
66 Approach to the Patient with Cancer 435
Dan L. Longo
67 Prevention and Early Detection of Cancer 441
Otis W. Brawley / Barnett S. Kramer
68 Cancer Genetics 447
Pat J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein
69 Cancer Cell Biology and Angiogenesis 453
Robert G. Fenton / Dan L. Longo
70 Principles of Cancer Treatment: Surgery, Chemotherapy, and BiologicTherapy 464
Edward A. Sausville / Dan L. Longo
71 Principles of Radiation Therapy 482
Stephen M. Hahn / Eli Glatstein
72 Infections in Patients with Cancer 489
Robert Finberg
73 Cancer of the Skin 497
Katarina G. Chiller / Carl Washington / Arthur J. Sober / Howard K. Koh
74 Head and Neck Cancer 503
Everett E. Vokes
75 Neoplasms of the Lung 506
John D. Minna
76 Breast Cancer 516
Marc E. Lippman
77 Gastrointestinal Tract Cancer 523
Robert J. Mayer
78 Tumors of the Liver and Biliary Tract 533
Jules L. Dienstag / Kurt J. Isselbacher
79 Pancreatic Cancer 537
Robert J. Mayer
80 Bladder and Renal Cell Carcinomas 539
Howard I. Scher / Robert J. Motzer
81 Hyperplasticand Malignant Diseases of the Prostate 543
Howard I. Scher
82 Testicular Cancer 550
Robert J. Motzer / George J. Bosl
83 Gynecologic Malignancies 553
Robert C. Young
84 Soft Tissue and Bone Sarcomas and Bone Metastases 558
Shreyaskumar R. Patel / Robert S. Benjamin
85 MetastaticCanc er of Unknown Primary Site 562
Richard M. Stone
86 ParaneoplasticSyndromes: Endocrinologic / Hematologic 566
J. Larry Jameson / Bruce E. Johnson
87 ParaneoplasticNeurologic Syndromes 571
Josep Dalmau / Myrna R. Rosenfeld
88 Oncologic Emergencies 575
Rasim Gucalp / Janice Dutcher
89 Late Consequences of Cancer and Its Treatment 583
Michael C. Perry / Dan L. Longo
SECTION 2 HEMATOPOIETIC DISORDERS
90 Iron Deficiency and Other Hypoproliferative Anemias 586
John W. Adamson
91 Hemoglobinopathies 593
Edward J. Benz
92 MegaloblasticAnemias 601
Bernard M. Babior / H. Franklin Bunn
93 HemolyticAnemias and Acute Blood Loss 607
H. Franklin Bunn / Wendell Rosse
94 AplasticAnemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes 617
Neal S. Young
95 Polycythemia Vera and Other Myeloproliferative Diseases 626
Jerry L. Spivak
96 Acute and Chronic Myeloid Leukemia 631
Meir Wetzler / John C. Byrd / Clara D. Bloomfield
97 Malignancies of Lymphoid Cells 641
James O. Armitage / Dan L. Longo
98 Plasma Cell Disorders 656
Dan L. Longo / Kenneth C. Anderson
99 Transfusion Biology and Therapy 662
Jeffery S. Dzieczkowski / Kenneth C. Anderson
100 HematopoieticCell Transplantation 668
Frederick R. Appelbaum
SECTION 3 DISORDERS OF HEMOSTASIS
101 Disorders of the Platelet and Vessel Wall 673
Robert I. Handin
102 Disorders of Coagulation and Thrombosis 680
Robert I. Handin
103 Antiplatelet, Anticoagulant, and Fibrinolytic Therapy 687
Steven R. Deitcher
Part Six
INFECTIOUS DISEASES
SECTION 1 BASIC CONSIDERATIONS IN INFECTIOUS DISEASES
104 Introduction to Infectious Diseases: Host–Pathogen Interactions 695
Lawrence C. Madoff / Dennis L. Kasper
105 Molecular Mechanisms of Microbial Pathogenesis 700
Gerald B. Pier
106 Approach to the Acutely Ill Infected Febrile Patient 706
Tamar F. Barlam / Dennis L. Kasper
107 Immunization Principles and Vaccine Use 713
Gerald T. Keusch / Kenneth J. Bart / Mark Miller
108 Health Advice for International Travel 725
J.S. Keystone / P.E. Kozarsky
SECTION 2 CLINICAL SYNDROMES: COMMUNITY-ACQUIRED INFECTIONS
109 Infective Endocarditis 731
Adolf W. Karchmer
110 Infections of the Skin, Muscle, and Soft Tissues 740
Dennis L. Stevens
111 Osteomyelitis 745
Jeffrey Parsonnet / James H. Maguire
112 Intraabdominal Infections and Abscesses 749
Dennis L. Kasper / Dori F. Zaleznik
113 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning 754
Joan R. Butterton / Stephen B. Calderwood
114 Clostridium difficile-Associated Disease, Including Pseudomembranous Colitis 760
Dale N. Gerding / Stuart Johnson
115 Sexually Transmitted Diseases: Overview and Clinical Approach 762
King K. Holmes
SECTION 3 CLINICAL SYNDROMES: NOSOCOMIAL INFECTIONS
116 Hospital-Acquired Infections 775
Robert A. Weinstein
117 Infections in Transplant Recipients 781
Robert Finberg / Joyce Fingeroth
SECTION 4 APPROACH TO THERAPY FOR BACTERIAL DISEASES
118 Treatment and Prophylaxis of Bacterial Infections 789
Gordon L. Archer / Ronald E. Polk
SECTION 5 DISEASES CAUSED BY GRAM-POSITIVE BACTERIA
119 Pneumococcal Infections 806
Daniel M. Musher
120 Staphylococcal Infections 814
Franklin D. Lowy
121 Streptococcal and Enterococcal Infections 823
Michael R. Wessels
122 Diphtheria and Other Corynebacterial Infections 832
Randall K. Holmes
123 Infections Caused by Listeria monocytogenes 837
Anne Schuchat / Claire V. Broome
124 Tetanus 840
Elias Abrutyn
125 Botulism 842
Elias Abrutyn
126 Gas Gangrene and Other Clostridial Infections 845
Dennis L. Kasper / Lawrence C. Madoff
SECTION 6 DISEASES CAUSED BY GRAM-NEGATIVE BACTERIA
127 Meningococcal Infections 849
David S. Stephens / Robert S. Munford / Lee M. Wetzler
128 Gonococcal Infections 855
Sanjay Ram / Peter A. Rice
129 Moraxella catarrhalis and Other Moraxella Species 862
Daniel M. Musher
130 Haemophilus Infections 864
Timothy F. Murphy
131 Infections Due to HACEK Group and Miscellaneous Gram-Negative Bacteria 867
Dennis L. Kasper / Tamar F. Barlam
132 Legionella Infection 870
Feng-Yee Chang / Victor L. Yu
133 Pertussis and Other Bordetella Infections 874
Scott A. Halperin
134 Diseases Caused by Gram-Negative EntericBac illi 878
Thomas A. Russo
135 Helicobacter pylori Infections 886
John C. Atherton / Martin J. Blaser
136 Infections Due to Pseudomonas Species and Related Organisms 889
Christopher A. Ohl / Matthew Pollack
137 Salmonellosis 897
Cammie F. Lesser / Samuel I. Miller
138 Shigellosis 902
Gerald T. Keusch / Dennis J. Kopecko
139 Infections Due to Campylobacter and Related Species 907
Martin J. Blaser
140 Cholera and Other Vibrioses 909
Matthew K. Waldor / Gerald T. Keusch
141 Brucellosis 914
Michael J. Corbel / Nicholas J. Beeching
142 Tularemia 917
Richard F. Jacobs
143 Plague and Other Yersinia Infections 921
David T. Dennis / Grant L. Campbell
144 Bartonella Infections, Including Cat-Scratch Disease 929
Lucy Stuart Tompkins
145 Donovanosis 932
Gavin Hart
SECTION 7 MISCELLANEOUS BACTERIAL INFECTIONS
146 Nocardiosis 934
Gregory A. Filice
147 Actinomycosis 937
Thomas A. Russo
148 Infections Due to Mixed Anaerobic Organisms 940
Dennis L. Kasper
SECTION 8 MYCOBACTERIAL DISEASES
149 Antimycobacterial Agents 946
Richard J. Wallace, Jr. / David E. Griffith
150 Tuberculosis 953
Mario C. Raviglione / Richard J. O’Brien
151 Leprosy (Hansen’s Disease) 966
Robert H. Gelber
152 Nontuberculous Mycobacteria 972
C. Fordham von Reyn
SECTION 9 SPIROCHETAL DISEASES
153 Syphilis 977
Sheila A. Lukehart
154 EndemicTreponematoses 985
Sheila A. Lukehart
155 Leptospirosis 988
Peter Speelman
156 Relapsing Fever 991
David T. Dennis / Edward B. Hayes
157 Lyme Borreliosis 995
Allen C. Steere
SECTION 10 DISEASES CAUSED BY RICKETTSIA, MYCOPLASMA, AND CHLAMYDIA
158 Rickettsial Diseases 999
David H. Walker / Didier Raoult / J. Stephen Dumler / Thomas J. Marrie
159 Infections Due to Mycoplasmas 1008
William M. McCormack
160 Chlamydial Infections 1011
Walter E. Stamm
SECTION 11 VIRAL DISEASES: GENERAL CONSIDERATIONS
161 Medical Virology 1019
Fred Wang / Elliott Kieff
162 Antiviral Chemotherapy, Excluding Antiretroviral Drugs 1027
Lindsey R. Baden / Raphael Dolin
SECTION 12 INFECTIONS DUE TO DNA VIRUSES
163 Herpes Simplex Viruses 1035
Lawrence Corey
164 Varicella-Zoster Virus Infections 1042
Richard J. Whitley
165 Epstein-Barr Virus Infections, Including Infectious Mononucleosis 1046
Jeffrey I. Cohen
166 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8 1049
Martin S. Hirsch
167 Molluscum Contagiosum and Other Poxviruses, Excluding Smallpox Virus 1053
Fred Wang
168 Parvovirus 1054
Neil R. Blacklow
169 Human Papillomavirus Infections 1056
Richard C. Reichman
SECTION 13 INFECTIONS DUE TO DNA AND RNA RESPIRATORY VIRUSES
170 Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome
(SARS) 1059
Raphael Dolin
171 Influenza 1066
Raphael Dolin
SECTION 14 INFECTIONS DUE TO HUMAN IMMUNODEFICIENCY VIRUS AND OTHER HUMAN RETROVIRUSES
172 The Human Retroviruses 1071
Dan L. Longo / Anthony S. Fauci
173 Human Immunodeficiency Virus Disease: AIDS and Related Disorders 1076
Anthony S. Fauci / H. Clifford Lane
SECTION 15 INFECTIONS DUE TO RNA VIRUSES
174 Viral Gastroenteritis 1140
Umesh D. Parashar / Roger I. Glass
175 Enteroviruses and Reoviruses 1143
Jeffrey I. Cohen
176 Measles (Rubeola) 1148
Anne Gershon
177 Rubella (German Measles) 1152
Anne Gershon
178 Mumps 1154
Anne Gershon
179 Rabies Virus and Other Rhabdoviruses 1155
Cathleen A. Hanlon / Lawrence Corey
180 Infections Caused by Arthropod- and Rodent-Borne Viruses 1161
Clarence J. Peters
181 Ebola and Marburg Viruses 1174
Clarence J. Peters
SECTION 16 FUNGAL AND ALGAL INFECTIONS
182 Diagnosis and Treatment of Fungal Infections 1176
John E. Bennett
183 Histoplasmosis 1179
John E. Bennett
184 Coccidioidomycosis 1180
John E. Bennett
185 Blastomycosis 1182
John E. Bennett
186 Cryptococcosis 1183
John E. Bennett
187 Candidiasis 1185
John E. Bennett
188 Aspergillosis 1188
John E. Bennett
189 Mucormycosis 1190
John E. Bennett
190 Miscellaneous Mycoses and Algal Infections 1191
John E. Bennett
191 Pneumocystis Infection 1194
Peter D. Walzer
SECTION 17 PROTOZOAL AND HELMINTHIC INFECTIONS: GENERAL CONSIDERATIONS
192 Laboratory Diagnosis of ParasiticInfec tions 1197
Charles E. Davis
193 Agents Used to Treat Infections Due to Parasites and Pneumocystis 1202
Thomas A. Moore
SECTION 18 PROTOZOAL INFECTIONS
194 Amebiasis and Infection with Free-Living Amebas 1214
Sharon L. Reed
195 Malaria and Babesiosis: Diseases Caused by Red Blood Cell Parasites 1218
Nicholas J. White / Joel G. Breman
196 Leishmaniasis 1233
Barbara L. Herwaldt
197 Trypanosomiasis 1238
Louis V. Kirchhoff
198 Toxoplasma Infection 1243
Lloyd H. Kasper
199 Protozoal Intestinal Infections and Trichomoniasis 1248
Peter F. Weller
SECTION 19 HELMINTHIC INFECTIONS
200 Trichinella and Other Tissue Nematodes 1253
Peter F. Weller
201 Intestinal Nematodes 1256
Peter F. Weller / Thomas B. Nutman
202 Filarial and Related Infections 1260
Thomas B. Nutman / Peter F. Weller
203 Schistosomiasis and Other Trematode Infections 1266
Adel A.F. Mahmoud
204 Cestodes 1272
A. Clinton White, Jr. / Peter F. Weller
Part Seven
BIOTERRORISM AND CLINICAL MEDICINE
205 Microbial Bioterrorism 1279
H. Clifford Lane / Anthony S. Fauci
206 Chemical Bioterrorism 1288
Charles G. Hurst / Jonathan Newmark / James A. Romano
207 Radiation Bioterrorism 1294
Zelig A. Tochner / Ofer Lehavi / Eli Glatstein
Part Eight
DISORDERS OF THE CARDIOVASCULAR SYSTEM
SECTION 1 DIAGNOSIS OF CARDIOVASCULAR DISORDERS
208 Approach to the Patient with Cardiovascular Disease 1301
Eugene Braunwald
209 Physical Examination of the Cardiovascular System 1304
Robert A. O’Rourke / Eugene Braunwald
210 Electrocardiography 1311
Ary L. Goldberger
211 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI / CT Imaging 1320
Rick A. Nishimura / Raymond J. Gibbons / James F. Glockner / A. Jamil Tajik
212 DiagnosticCardiac Catheterization and Angiography 1327
Donald S. Baim / William Grossman
SECTION 2 DISORDERS OF RHYTHM
213 The Bradyarrhythmias: Disorders of Sinus Node Function and AV Conduction Disturbances 1333
Mark E. Josephson / Peter Zimetbaum
214 The Tachyarrhythmias 1342
Mark E. Josephson / Peter Zimetbaum
SECTION 3 DISORDERS OF THE HEART
215 Normal and Abnormal Myocardial Function 1358
Eugene Braunwald
216 Heart Failure and Cor Pulmonale 1367
Eugene Braunwald
217 CardiacTransplantation and Prolonged Assisted Circulation 1378
Sharon A. Hunt
218 Congenital Heart Disease in the Adult 1381
John S. Child / William F. Friedman
219 Valvular Heart Disease 1390
Eugene Braunwald
220 Pulmonary Hypertension 1403
Stuart Rich
221 Cardiomyopathy and Myocarditis 1408
Joshua Wynne / Eugene Braunwald
222 Pericardial Disease 1414
Eugene Braunwald
223 CardiacTumors, CardiacManifestations of SystemicDiseases, and TraumaticCardiac
Injury 1420
Wilson S. Colucci / Daniel T. Price
SECTION 4 VASCULAR DISEASE
224 The Pathogenesis of Atherosclerosis 1425
Peter Libby
225 Prevention and Treatment of Atherosclerosis 1430
Peter Libby
226 Ischemic Heart Disease 1434
Andrew P. Selwyn / Eugene Braunwald
227 Unstable Angina and Non-ST-Elevation Myocardial Infarction 1444
Christopher P. Cannon / Eugene Braunwald
228 ST-Segment Elevation Myocardial Infarction 1448
Elliott M. Antman / Eugene Braunwald
229 Percutaneous Coronary Revascularization 1459
Donald S. Baim
230 Hypertensive Vascular Disease 1463
Naomi D.L. Fisher / Gordon H. Williams
231 Diseases of the Aorta 1481
Victor J. Dzau / Mark A. Creager
232 Vascular Diseases of the Extremities 1486
Mark A. Creager / Victor J. Dzau
Part Nine
DISORDERS OF THE RESPIRATORY SYSTEM
SECTION 1 DIAGNOSIS OF RESPIRATORY DISORDERS
233 Approach to the Patient with Disease of the Respiratory System 1495
Jeffrey M. Drazen / Steven E. Weinberger
234 Disturbances of Respiratory Function 1498
Steven E. Weinberger / Jeffrey M. Drazen
235 DiagnosticProc edures in Respiratory Disease 1505
Steven E. Weinberger / Jeffrey M. Drazen
SECTION 2 DISEASES OF THE RESPIRATORY SYSTEM
236 Asthma 1508
E.R. McFadden, Jr.
237 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia 1516
Joel N. Kline / Gary W. Hunninghake
238 Environmental Lung Diseases 1521
Frank E. Speizer
239 Pneumonia 1528
Thomas J. Marrie / G. Douglas Campbell / David H. Walker / Donald E. Low
240 Bronchiectasis 1541
Steven E. Weinberger
241 CysticFibrosis 1543
Richard C. Boucher
242 ChronicObstruc tive Pulmonary Disease 1547
John J. Reilly, Jr. / Edwin K. Silverman / Steven D. Shapiro
243 Interstitial Lung Diseases 1554
Talmadge E. King, Jr.
244 Pulmonary Thromboembolism 1561
Samuel Z. Goldhaber
245 Disorders of the Pleura, Mediastinum, Diaphragm, and Chest Wall 1565
Richard W. Light
246 Disorders of Ventilation 1569
Eliot A. Phillipson
247 Sleep Apnea 1573
Eliot A. Phillipson
248 Lung Transplantation 1576
Elbert P. Trulock / G. Alexander Patterson / Joel D. Cooper
Part Ten
CRITICAL CARE MEDICINE
SECTION 1 RESPIRATORY CRITICAL CARE
249 Principles of Critical Care Medicine 1581
John P. Kress / Jesse B. Hall
250 Respiratory Failure 1588
Craig Lilly / Edward P. Ingenito / Steven D. Shapiro
251 Acute Respiratory Distress Syndrome 1592
Bruce D. Levy / Steven D. Shapiro
252 Mechanical Ventilatory Support 1595
Edward P. Ingenito / Jeffrey M. Drazen
SECTION 2 SHOCK AND CARDIAC ARREST
253 Approach to the Patient with Shock 1600
Ronald V. Maier
254 Severe Sepsis and SepticShoc k 1606
Robert S. Munford
255 CardiogenicShoc k and Pulmonary Edema 1612
Judith S. Hochman / David Ingbar
256 Cardiovascular Collapse, Cardiac Arrest, and Sudden CardiacDeath 1618
Robert J. Myerburg / Agustin Castellanos
SECTION 3 NEUROLOGIC CRITICAL CARE
257 Acute Confusional States and Coma 1624
Allan H. Ropper
258 Critical Care Neurology 1631
J. Claude Hemphill
Part Eleven
DISORDERS OF THE KIDNEY AND URINARY TRACT
259 Adaptation to Renal Injury 1639
Robert M. Brenner / Barry M. Brenner
260 Acute Renal Failure 1644
Hugh R. Brady / Barry M. Brenner
261 ChronicRenal Failure 1653
Karl Skorecki / JacobGreen / Barry M. Brenner
262 Dialysis in the Treatment of Renal Failure 1663
Ajay K. Singh / Barry M. Brenner
263 Transplantation in the Treatment of Renal Failure 1668
Charles B. Carpenter / Edgar L. Milford / Mohamed H. Sayegh
264 Glomerular Diseases 1674
Hugh R. Brady / Yvonne M. O’Meara / Barry M. Brenner
265 Tubular Disorders 1694
John R. Asplin / Fredric L. Coe
266 Tubulointerstitial Diseases of the Kidney 1702
Alan S. L. Yu / Barry M. Brenner
267 Vascular Injury to the Kidney 1706
Kamal F. Badr / Barry M. Brenner
268 Nephrolithiasis 1710
John R. Asplin / Fredric L. Coe / Murray J. Favus
269 Urinary Tract Infections and Pyelonephritis 1715
Walter E. Stamm
270 Urinary Tract Obstruction 1722
Julian L. Seifter / Barry M. Brenner
Part Twelve
DISORDERS OF THE GASTROINTESTINAL SYSTEM
SECTION 1 DISORDERS OF THE ALIMENTARY TRACT
271 Approach to the Patient with Gastrointestinal Disease 1725
William L. Hasler / Chung Owyang
272 Gastrointestinal Endoscopy 1730
Mark Topazian
273 Diseases of the Esophagus 1739
Raj K. Goyal
274 PepticUlc er Disease and Related Disorders 1746
John Del Valle
275 Disorders of Absorption 1763
Henry J. Binder
276 Inflammatory Bowel Disease 1776
Sonia Friedman / Richard S. Blumberg
277 Irritable Bowel Syndrome 1789
Chung Owyang
278 Familial Mediterranean Fever and Other Hereditary Recurrent Fevers 1793
Daniel L. Kastner
279 Common Diseases of the Colon and Anorectum and Mesenteric Vascular
Insufficiency 1795
Susan L. Gearhart / Gregory Bulkley
280 Acute Intestinal Obstruction 1803
William Silen
281 Acute Appendicitis and Peritonitis 1805
William Silen
SECTION 2 LIVER AND BILIARY TRACT DISEASE
282 Approach to the Patient with Liver Disease 1808
Marc Ghany / Jay H. Hoofnagle
283 Evaluation of Liver Function 1813
Daniel S. Pratt / Marshall M. Kaplan
284 The Hyperbilirubinemias 1817
Allan W. Wolkoff
285 Acute Viral Hepatitis 1822
Jules L. Dienstag / Kurt J. Isselbacher
286 Toxicand Drug-Induced Hepatitis 1838
Jules L. Dienstag / Kurt J. Isselbacher
287 ChronicHepatitis 1844
Jules L. Dienstag / Kurt J. Isselbacher
288 Alcoholic Liver Disease 1855
Mark E. Mailliard / Michael F. Sorrell
289 Cirrhosis and Its Complications 1858
Raymond T. Chung / Daniel K. Podolsky
290 Infiltrative, Genetic, and Metabolic Diseases Affecting the Liver 1869
Daniel K. Podolsky
291 Liver Transplantation 1873
Jules L. Dienstag
292 Diseases of the Gallbladder and Bile Ducts 1880
Norton J. Greenberger / Gustav Paumgartner
SECTION 3 DISORDERS OF THE PANCREAS
293 Approach to the Patient with Pancreatic Disease 1891
Phillip P. Toskes / Norton J. Greenberger
294 Acute and Chronic Pancreatitis 1895
Norton J. Greenberger / Phillip P. Toskes
Part Thirteen
DISORDERS OF THE IMMUNE SYSTEM, CONNECTIVE TISSUE, AND JOINTS
SECTION 1 THE IMMUNE SYSTEM IN HEALTH AND DISEASE
295 Introduction to the Immune System 1907
Barton F. Haynes / Anthony S. Fauci
296 The Major Histocompatibility Gene Complex 1930
Gerald T. Nepom / Joel D. Taurog
297 Primary Immune Deficiency Diseases 1939
Max D. Cooper / Harry W. Schroeder, Jr.
SECTION 2 DISORDERS OF IMMUNE-MEDIATED INJURY
298 Allergies, Anaphylaxis, and SystemicMastoc ytosis 1947
K. Frank Austen
299 Autoimmunity and Autoimmune Diseases 1956
Peter E. Lipsky / Betty Diamond
300 SystemicLupus Erythematosus 1960
Bevra Hannahs Hahn
301 Rheumatoid Arthritis 1968
Peter E. Lipsky
302 RheumaticFever 1977
Edward L. Kaplan
303 Systemic Sclerosis (Scleroderma) and Related Disorders 1979
Bruce C. Gilliland
304 Sjo¨gren’s Syndrome 1990
Haralampos M. Moutsopoulos
305 The Spondyloarthritides 1993
Joel D. Taurog
306 The Vasculitis Syndromes 2002
Michael C. Sneller / Carol A. Langford / Anthony S. Fauci
307 Behc¸et’s Syndrome 2014
Haralampos M. Moutsopoulos
308 Relapsing Polychondritis 2015
Bruce C. Gilliland
309 Sarcoidosis 2017
Ronald G. Crystal
310 Amyloidosis 2024
Jean D. Sipe / Alan S. Cohen
SECTION 3 DISORDERS OF THE JOINTS AND ADJACENT TISSUES
311 Approach to Articular and Musculoskeletal Disorders 2029
John J. Cush / Peter E. Lipsky
312 Osteoarthritis 2036
Kenneth D. Brandt
313 Gout and Other Crystal Arthropathies 2046
Antonio J. Reginato
314 Infectious Arthritis 2050
Lawrence C. Madoff / Scott J. Thaler / James H. Maguire
315 Fibromyalgia, Arthritis Associated with Systemic Diseases, and Other Arthritides 2055
Bruce C. Gilliland
316 Periarticular Disorders of the Extremities 2064
Bruce C. Gilliland
Part Fourteen
ENDOCRINOLOGY AND METABOLISM
SECTION 1 ENDOCRINOLOGY
317 Principles of Endocrinology 2067
J. Larry Jameson
318 Disorders of the Anterior Pituitary and Hypothalamus 2076
Shlomo Melmed / J. Larry Jameson
319 Disorders of the Neurohypophysis 2097
Gary L. Robertson
320 Diseases of the Thyroid Gland 2104
J. Larry Jameson / Anthony P. Weetman
321 Disorders of the Adrenal Cortex 2127
Gordon H. Williams / Robert G. Dluhy
322 Pheochromocytoma 2148
Lewis Landsberg / James B. Young
323 Diabetes Mellitus 2152
Alvin C. Powers
324 Hypoglycemia 2180
Philip E. Cryer
325 Disorders of the Testes and Male Reproductive System 2185
Shalendar Bhasin / J. Larry Jameson
326 Disorders of the Ovary and Female Reproductive Tract 2198
Bruce R. Carr / Karen D. Bradshaw
327 The Menopause Transition and Postmenopausal Hormone Therapy 2209
JoAnn E. Manson / Shari S. Bassuk
328 Disorders of Sexual Differentiation 2214
John C. Achermann / J. Larry Jameson
329 Endocrine Tumors of the Gastrointestinal Tract and Pancreas 2220
Robert T. Jensen
330 Disorders Affecting Multiple Endocrine Systems 2231
Steven I. Sherman / Robert F. Gagel
SECTION 2 DISORDERS OF BONE AND MINERAL METABOLISM
331 Bone and Mineral Metabolism in Health and Disease 2238
F. Richard Bringhurst / Marie B. Demay / Stephen M. Krane / Henry M. Kronenberg
332 Diseases of the Parathyroid Gland and Other Hyper- and Hypocalcemic Disorders 2249
John T. Potts, Jr.
333 Osteoporosis 2268
Robert Lindsay / Felicia Cosman
334 Paget Disease and Other Dysplasias of Bone 2279
Murray J. Favus / Tamara J. Vokes
SECTION 3 DISORDERS OF INTERMEDIARY METABOLISM
335 Disorders of Lipoprotein Metabolism 2286
Daniel J. Rader / Helen H. Hobbs
336 Hemochromatosis 2298
Lawrie W. Powell
337 The Porphyrias 2303
Robert J. Desnick
338 Disorders of Purine and Pyrimidine Metabolism 2308
Robert L. Wortmann
339 Wilson Disease 2313
George J. Brewer
340 Lysosomal Storage Diseases 2315
Robert J. Hopkin / Gregory A. Grabowski
341 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate
Metabolism 2319
Yuan-Tsong Chen
342 Inherited Disorders of Connective Tissue 2324
Darwin J. Prockop / Leena Ala-Kokko
343 Inherited Disorders of Amino Acid Metabolism Presenting in Adults 2331
Nicola Longo
344 Inherited Defects of Membrane Transport 2335
Nicola Longo
Part Fifteen
NEUROLOGIC DISORDERS
SECTION 1 DIAGNOSIS OF NEUROLOGIC DISORDERS
345 Neurobiology of Disease 2339
Stephen L. Hauser / M. Flint Beal
346 Approach to the Patient with Neurologic Disease 2344
Joseph B. Martin / Daniel H. Lowenstein / Stephen L. Hauser
347 Neuroimaging in NeurologicDisorders 2350
William P. Dillon
SECTION 2 DISEASES OF THE CENTRAL NERVOUS SYSTEM
348 Seizures and Epilepsy 2357
Daniel H. Lowenstein
349 Cerebrovascular Diseases 2372
Wade S. Smith / S. Claiborne Johnston / J. Donald Easton
350 Alzheimer’s Disease and Other Dementias 2393
Thomas D. Bird / Bruce L. Miller
351 Parkinson’s Disease and Other Movement Disorders 2406
Mahlon R. DeLong / Jorge L. Juncos
352 AtaxicDisorders 2418
Roger N. Rosenberg
353 AmyotrophicLateral Sclerosis and Other Motor Neuron Diseases 2424
Robert H. Brown, Jr.
354 Disorders of the AutonomicNervous System 2428
Phillip A. Low / John W. Engstrom
355 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders 2434
M. Flint Beal / Stephen L. Hauser
356 Diseases of the Spinal Cord 2438
Stephen L. Hauser / Allan H. Ropper
357 Concussion and Other Head Injuries 2447
Allan H. Ropper
358 Primary and MetastaticTumors of the Nervous System 2452
Stephen M. Sagar / Mark A. Israel
359 Multiple Sclerosis and Other Demyelinating Diseases 2461
Stephen L. Hauser / Douglas S. Goodin
360 Meningitis, Encephalitis, Brain Abscess, and Empyema 2471
Karen L. Roos / Kenneth L. Tyler
361 Chronicand Recurrent Meningitis 2490
Walter J. Koroshetz / Morton N. Swartz
362 Prion Diseases 2495
Stanley B. Prusiner / Bruce Miller
SECTION 3 NERVE AND MUSCLE DISORDERS
363 Approach to the Patient with Peripheral Neuropathy 2500
Arthur K. Asbury
364 Charcot-Marie-Tooth Disease and Other Inherited Neuropathies 2510
Philip F. Chance / Thomas D. Bird
365 Guillain-Barre´ Syndrome and Other Immune- Mediated Neuropathies 2513
Stephen L. Hauser / Arthur K. Asbury
366 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction 2518
Daniel B. Drachman
367 Approach to the Patient with Muscle Disease 2524
Jerry R. Mendell
368 Muscular Dystrophies and Other Muscle Diseases 2527
Robert H. Brown, Jr. / Jerry R. Mendell
369 Polymyositis, Dermatomyositis, and Inclusion Body Myositis 2540
Marinos C. Dalakas
SECTION 4 CHRONIC FATIGUE SYNDROME
370 ChronicFatigue Syndrome 2545
Stephen E. Straus
SECTION 5 PSYCHIATRIC DISORDERS
371 Mental Disorders 2547
Victor I. Reus
SECTION 6 ALCOHOLISM AND DRUG DEPENDENCY
372 Alcohol and Alcoholism 2562
Marc A. Schuckit
373 Opioid Drug Abuse and Dependence 2567
Marc A. Schuckit / David S. Segal
374 Cocaine and Other Commonly Abused Drugs 2570
Jack H. Mendelson / Nancy K. Mello
375 Nicotine Addiction 2573
David M. Burns
Part Sixteen
POISONING, DRUG OVERDOSE, AND ENVENOMATION
376 Heavy Metal Poisoning 2577
Howard Hu
377 Poisoning and Drug Overdosage 2580
Christopher H. Linden / Michael J. Burns
378 Disorders Caused by Reptile Bites and Marine Animal Exposures 2593
Paul S. Auerbach / Robert L. Norris
379 Ectoparasite Infestations and Arthropod Bites and Stings 2600
James H. Maguire / Richard J. Pollack / Andrew Spielman
APPENDICES
Laboratory Values of Clinical Importance A-1
Alexander Kratz / Patrick M. Sluss / James L. Januzzi, Jr. / Kent B. Lewandrowski
A. Reference Values for Laboratory Tests A-1
B. Reference Values for Specific Analytes A-11
C. Special Function Tests A-13
D. Miscellaneous A-15
INDEX I-1
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