Apoptosis, Senescence, and Cancer Second Edition
Buku ini diterbitkan tahun 2007 oleh Humana Press Inc. Totowa, New Jersey merupakan buku edisi kedua..
Judul: Apoptosis, Senescence, and Cancer Second Edition
Oleh: David A. Gerwirtz, et al (Editor)
Penerbit: Humana Press Inc. Totowa, New Jersey
Tahun: 2007
Jumlah Halaman: 586 hal.
Editor:
David A. Gewirtz
Department of Pharmacology and Toxicology and Massey Cancer
Center, Virginia Commonwealth University, Richmond, VA
Shawn E. Holt
Departments of Medicine, Pharmacology and Toxicology, Biochemistry
and Massey Cancer Center, Virginia Commonwealth, Richmond, VA
Steven Grant
Departments of Pathology, Human Genetics, Pharmacology and
Toxicology, Biochemistry and Massey Cancer Center, Virginia
Commonwealth, Richmond, VA
Lingkup Pembahasan:
Tujuan dari buku ini adalah untuk memberikan kontribusi untuk pemahaman tentang penangkapan pertumbuhan dan jalur kematian sel mediasi respon terhadap kemoterapi pada sel tumor. Buku
dibagi menjadi enam bagian. Pertama meninjau jalur kematian sel utama. Kedua
mengembangkan tema telomere, telomerase, dan penuaan dalam stabilitas genetik dan
tumorigenesis. Yang ketiga menyediakan diseksi mendalam tentang kerusakan DNA kritis
dan respon jalur sinyal. The penawaran keempat dengan keterbatasan mendasar
terapi yang diberikan oleh resistensi obat, serta pendekatan saat ini untuk menghindari
atau melemahkan resistensi obat. Bagian kelima dan keenam memberikan analisis kami
pemahaman tentang tanggapan terhadap kedua strategi konvensional dan baru dikembangkan
terapi-terapi terhadap kanker.
Diharapankan bahwa buku ini akan memberikan pada para ilmuwan dasar dan dokter dengan
pemahaman yang lebih dalam dan lebih menyeluruh dari respon seluler dari sel-sel ganas untuk
modalitas terapi umum, yang dapat menentukan efektivitas pengobatan, baik dalam tahap awal penyakit dan tahap terakhir, termasuk kekambuhan dan penyakit metastasis.
Daftar Isi:
Preface v
Contributors xi
Introduction and Overview xv
Part I: Apoptosis and Alternative Modes of Cell Death
1 The Intrinsic Pathway of Apoptosis 3
Scott H. Kaufmann
2 The Extrinsic Pathway of Apoptosis 31
M. Stacey Ricci, and Wafik S. El-Deiry
3 Evaluating the Importance of Apoptosis and Other Determinants of Cell Death and
Survival 55
Bradly G. Wouters and Roland K. Chiu
4 Mitotic Catastrophe 73
Fiorenza Ianzini and Michael A. Mackey
5 Autophagy and Autophagic Cell Death 93
Mojgan Djavaheri-Mergny, Joëlle Botti, and Patrice Codogno
6 Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression
and Metastasis 109
David J. McConkey and Victor Bondar
Part II: Telomeres and Telomerase, Senescence, Genomic Instability, and Tumorigenesis
7 Structure and Function of the Telomere 125
Jay E. Johnson, and Dominique Broccoli
8 Overview of Senescence 145
Ruben D. Ramirez
9 Contributions of Telomerase to Tumorigenesis .159
Richard Possemato and William C. Hahn
10 The Role of Telomeres in Genomic Instability 173
John P. Murnane
Part III: DNA Damage Response, Signaling Pathways, and Tumorigenesis
11 Overview of the DNA Damage Checkpoint: ATM and ATR 193
Aude Dupré and Jean Gautier
12 Interactions Between Myc- and Cyclin-Dependent Kinase Inhibitors in Cancer 223
Kirsteen H. Maclean, and John L. Cleveland
13 Interplay Between _H2AX and 53BP1 Pathways in DNA Double-Strand Break Repair
Response 243
Fatouros Chronis and Emmy P. Rogakou
14 DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and
Chemotherapy 265
Lawrence F. Povirk
Part IV: Resistance and Sensitization
15 Resistance/Signaling Pathways 281
Paul Dent, David T. Curiel and Paul B. Fisher
16 Ceramide and Multidrug Resistance 299
Myles C. Cabot
17 Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling 313
Debra L. Smith, Laura K. Nolden, Gordon B. Mills, and Yiling Lu
18 The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy 335
Gregory W. Allen and Paul M. Harari
Part V: Established Cancer Therapies
19 Antimetabolites 361
Janet A. Houghton
20 Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexes 383
Olivier Sordet, Yves Pommier, and Eric Solary
21 Perturbations of Cellular Functions by Topoisomerase II Inhibitors: All Roads Lead to
Cell Death? 407
Annette K. Larsen and Andrzej Skladanowski
22 The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and
Platinum Drugs 423
Jan M. Woynarowski and Barbara A. Woynarowska
23 Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-
Stabilizing Agents 465
Laura E. Klein and Susan Band Horwitz
24 Tyrosine Kinase Inhibitors 477
Michael Deininger
Part VI: Recent and Developing Cancer Therapies
25 Monoclonal Antibodies in Lymphomas 511
Richard R. Furman, John P. Leonard, Julian Decter, and Morton Coleman
26 Role of Apoptosis in Anti-Angiogenic Cancer Therapies .537
Jennifer A. Doll, Jennifer E. Hobbs, and Gerald A. Soff
27 Photodynamic Therapy-Induced Apoptosis .557
Nancy L. Oleinick, Rachel L. Morris, and Anna-Liisa Nieminen
28 Modulation of TRAIL Signaling for Cancer Therapy 579
Simone Fulda and Klaus-Michael Debatin
Index 593
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