Living Donor Organ Transplantation
Buku Ini adalah buku diterbitkan tahun 2008 McGraw-Hill Companies, Inc. USA adalah buku edisi Pertama.
Judul: Living Donor Organ Transplantation
Oleh: Rainer W.G. Groessner et al (Editor)
Penerbit: McGraw-Hill Companies, Inc. USA
Tahun: 2008
Jumlah Halaman: 855 hal.
Editor:
Rainer W.G. Gruessner, MD
University of Arizona, Tucson
Enrico Benedetti, MD
University of Illinois, Chicago
Lingkup Pembahasan:
Buku ini merupakan upaya bersama antara divisi transplantasi di Universitas Minnesota, Minneapolis, dan University of Illinois, Chicago. Keduanya telah melakukan transplantasi donor hidup dari semua organ perut; 1 dari 2 lembaga ini juga telah melakukan pulau donor hidup dan transplantasi paru-paru. Sejak tahun 2002, 2 divisi transplantasi donor hidup ini melakukan transplantasi organ perut, diadakan setiap tahun. 3 konferensi diadakan sejauh dibawa bersama-sama dibedakan sarjana dari Asia, Eropa, dan Amerika Utara. Proses dari 2004dan 2006 konferensi diterbitkan dalam literatur peer-review, transplantasi 2 divisi untuk menghasilkan buku ini.
Tujuan dari editor adalah untuk merakit kontribusi ilmiah dari para ahli yang paling terkenal dalam bidang ini, termasuk orang-orang yang telah merintis aspek prosedur bedah donor hidup. Kami merasa terhormat bahwa Dr Murray, dalam kata pengantarnya, dijelaskan awal pengalaman dengan transplantasi ginjal donor hidup. Kami juga berterima kasih kepada Dr Francis Delmonico yang, dalam kapasitasnya sebagai presiden dari Jaringan Serikat untuk Organ Sharing dari Juni 25, 2005, hingga 30 Juni 2006, disorot 2 state-of-the-art pertemuan pada donor hidup transplantasi bahwa ia telah terorganisir. Pertemuan pertama, diadakan di Amsterdam pada bulan Desember 2004, difokuskan pada perawatan hidup donor ginjal; pertemuan kedua, yang diadakan di Vancouver di September 2005, difokuskan pada perawatan paru-paru hidup, hati, pankreas, dan donor usus.
Buku ini terdiri atas 4 bagian. 4-bagian buku ini dirancang untuk memberikan gambaran tentang transplantasi donor hidup. Berbagai topik prosedural menyentuh, dari konseling donor dan
insentif keuangan kepada penerima pemeriksaan dan hasil. Berbagai topik prosedural menyentuh, dari konseling donor dan insentif keuangan kepada penerima pemeriksaan dan hasil. Refleksi pribadi pelopor transplantasi menawarkan latar belakang sejarah, sementara perhatian yang cukup juga dibayar untuk kemungkinan masa depan dalam bidang yang selalu berubah. Masalah bedah dan medis spesifik untuk donor perut transplantasi organ hidup dibahas secara rinci, memberikan banyak informasi untuk kedua pemula dan ahli.
Target utama buku ini meliputi ahli bedah transplantasi dan dokter, bersama dengan para peneliti di medan terkait seperti nefrologi, hepatologi, gastroenterologi, endokrinologi, patologi, imunologi, radiologi, dan etika. Sebuah referensi kognitif kerja, juga akan menarik bagi rekan-rekan transplantasi, warga, mahasiswa kedokteran, koordinator, perawat, dan pekerja sosial, serta administrator rumah sakit dan profesional medis lainnya.
Daftar isi:
FOREWORD xv
Joseph E. Murray, MD
PREFACE xvii
Rainer W.G. Gruessner, MD, Enrico Benedetti, MD
COMMENTARY: THE AMSTERDAM AND VANCOUVER xxix
CONFERENCES ON LIVING ORGAN DONATION
Francis L. Delmonico, MD
PART I: GENERAL ASPECTS OF LIVING DONOR ORGAN TRANSPLANTATION
CHAPTER 1 INTRODUCTION AND RATIONALE 3
Rainer W.G. Gruessner, MD, Sarah Taranto, BA, Angelika C. Gruessner, PhD
CHAPTER 2 CULTURAL DIFFERENCES IN LIVING ORGAN DONATION: A GLOBAL PERSPECTIVE 6
Clive O. Callender, MD, Micean Johnikin, MS, Patrice Miles
CHAPTER 3 ETHICAL AND LEGAL ISSUES 16
3.1 THE AMERICAN PERSPECTIVE 16
David C. Cronin II, MD, PhD, Mark Siegler, MD
3.2 THE ASIAN PERSPECTIVE 23
3.3 THE EUROPEAN PERSPECTIVE 37
Thomas Gutmann, PhD, MA, Walter G. Land, MD
CHAPTER 4 DONOR COUNSELING AND CONSENT 43
4.1 TEACHING AND TESTING THE KNOWLEDGE AND THINKING OF LIVING ORGAN
DONORS 43
Ro ert W. Steiner, MD, Christine A. Frederici, LCSW, Rodolfo R. Batarse, MD, Bernard
Gert, PhD
4.2 INFORMED CONSENT 47
Aaron Spital, MD
4.3 DONOR ADVOCACY 54
David M. Kashmer, MD, Tim Schmitt, MD, Ken Brayman, MD, PhD
CHAPTER 5 NONDIRECTED AND CONTROVERSIAL DONORS 57
Arthur J. Matas, MD
CHAPTER 6 SOCIAL ISSUES 64
Thomas R. McCune, MD
PART II: PAID LEGAL AND ILLEGAL ORGAN DONATION
CHAPTER 7 CURRENT FINANCIAL INCENTIVES 73
7.1 INCENTIVES IN WESTERN COUNTRIES: THE WISCONSIN MODEL 73
Steve Wieckert, Scott Becher, Hans W. Sollinger, MD, PhD
7.2 INCENTIVES IN NON-WESTERN COUNTRIES: THE IRANIAN MODEL 75
Ahad J. Ghods, MD
CHAPTER 8 PAID LEGAL ORGAN DONATION 81
8.1 PRO: THE CLINICIAN’S PERSPECTIVE 81
Arthur J. Matas, MD
8.2 PRO: THE PHILOSOPHER’S PERSPECTIVE 88
Janet Radcliffe-Richards, BA, MA, Bphil
8.3 CON: THE CLINICIAN’S PERSPECTIVE 94
Francis L. Delmonico, MD
8.4 CON: THE ETHICIST’S PERSPECTIVE 98
Jeffrey Kahn, PhD, MPH
CHAPTER 9 CHALLENGES OF PAID ORGAN DONATION FOR PUBLIC HEALTH CARE POLICY 100
Mark J. Cherry, PhD
CHAPTER 10 ILLEGAL ORGAN TRADE: GLOBAL JUSTICE AND THE TRAFFIC IN HUMAN ORGANS 106
Nancy Scheper-Hughes, PhD
CHAPTER 11 THE IMPACT OF THE INTERNET ON PAID LEGAL AND ILLEGAL ORGAN DONATION 122
W. Ben Vernon, MD
PART III: ORGAN-SPECIFIC ASPECTS OF LIVING DONOR ABDOMINAL ORGAN TRANSPLANTATION
SECTION I KIDNEY TRANSPLANTATION
CHAPTER 12 KIDNEY TRANSPLANTATION: PERSONAL REFLECTIONS 131
John S. Najarian, MD
CHAPTER 13 HISTORY OF LIVING DONOR KIDNEY TRANSPLANTATION 133
Luis H. Toledo-Pereyra, MD, Alexander Horacio Toledo, MD
CHAPTER 14 KIDNEY TRANSPLANTATION: GEOGRAPHICAL DIFFERENCES 139
Roberts S. Kalil, MD, Lawrence G. Hunsicker, MD
CHAPTER 15 KIDNEY TRANSPLANTATION: THE DONOR 144
15.1 SELECTION AND WORKUP 144
Mark E. Rosenberg, MD, Cathy Garvey, RN, Cheryl Jacobs, MS, LICSW
15.2 THE MARGINAL DONOR 154
E. Steve Woodle, MD, Mahmound El Khatib, MD
15.3 IMMUNOLOGIC EVALUATION 158
Andrea A. Zachary, PhD
15.4 ANESTHESIOLOGIC CONSIDERATIONS 163
David S. Beebe, MD
15.5 SURGICAL PROCEDURES 165
15.6 PERIOPERATIVE CARE OF THE KIDNEY DONOR 198
Mark L. Sturdevant, MD, Rainer W.G. Gruessner, MD
15.7 DONOR MORBIDITY AND MORTALITY 200
Burak Kocak, MD, Joseph R. Leventhal, MD, PhD
15.8 LONG-TERM OUTCOME 205
Arthur J. Matas, MD, Hassan N. Ibrahim, MD, MS
15.9 PSYCHOLOGICAL ASPECTS 212
Annette Lennerling, RN, MSc, PhD
CHAPTER 16 KIDNEY TRANSPLANTATION: THE RECIPIENT 217
16.1 SELECTION AND WORKUP 217
Rahul Koushik, MD, Bertram L. Kasiske, MD
16.2 ANESTHESIOLOGIC CONSIDERATIONS 224
David S. Beebe, MD
16.3 SURGICAL PROCEDURES 227
Howard Sankary, MD, Enrico Benedetti, MD
16.4 ISCHEMIA AND REPERFUSION INJURY 232
Stefan G. Tullius, MD, Nicholas L. Tilney, MD
16.5 PERIOPERATIVE CARE 239
Mark L. Sturdevant, MD, Vincent Casingal, MD, Rainer W.G. Gruessner, MD
16.6 POSTTRANSPLANT COMPLICATIONS 242
Amer Rajab, MD, Anatolie Usatii, MD, Ronald M. Ferguson, MD, PhD
16.7 IMMUNOSUPPRESSIVE THERAPY 252
David Axelrod, MD, MBA, Dixon B. Kaufman, MD, PhD
16.8 IMMUNOBIOLOGY 265
Gunilla Einecke, MD, Philip F. Halloran, MD, PhD
16.9 RECURRENCE OF DISEASE 271
Abel E. Tello, MD, Hassan N. Ibrahim, MD, MS
16.10 RETRANSPLANTATION 282
Akinlolu O. Ojo, MD, Laura L. Christensen, MS, Fu Luan, MD
16.11 PEDIATRIC ISSUES 287
16.12 PREEMPTIVE LIVING TRANSPLANTATION: THE IDEAL THERAPEUTIC
MODALITY FOR END-STAGE RENAL DISEASE 313
Herwig-Ulf Meier-Kriesche, MD, Jesse D. Schold, MStat, MEd
16.13 LONG-TERM OUTCOME 319
J. Michael Cecka, PhD
16.14 IMMUNOLOGIC ISSUES 326
Junchao Cai, MD, PhD, Paul Terasaki, PhD
16.15 LIVING DONOR KIDNEY TRANSPLANTATION AND MALIGNANCY 328
E. Steve Woodle, MD, Thomas G. Gross, MD, Rita Alloway, PharmD,
Amit D. Tevar, MD, Joseph Buell, MD
16.16 STRATEGIES TO MAXIMIZE THE DONOR POOL 336
CHAPTER 17 KIDNEY TRANSPLANTATION: COST ANALYSIS 364
Mark A. Schnitzler, PhD, Thomas Burroughs, PhD, Steven K. Takemoto, PhD
SECTION II PANCREAS TRANSPLANTATION
CHAPTER 18 HISTORY OF AND RATIONALE FOR PANCREAS
TRANSPLANTATION 369
18.1 HISTORY OF LIVING DONOR PANCREAS TRANSPLANTATION 369
David E. R. Sutherland, MD, PhD, John S. Najarian, MD, Rainer W.G. Gruessner, MD
18.2 RATIONALE FOR LIVING DONOR PANCREAS TRANSPLANTS 383
Rainer W.G. Gruessner, MD
CHAPTER 19 PANCREAS TRANSPLANTATION: THE DONOR 385
19.1 SELECTION AND WORKUP 385
Elizabeth R. Seaquist, MD, Rainer W.G. Gruessner, MD
19.2 SURGICAL PROCEDURES AND PERIOPERATIVE CARE 389
19.3 MORBIDITY, MORTALITY, AND LONG-TERM OUTCOME 398
Rainer W.G. Gruessner, MD
CHAPTER 20 PANCREAS TRANSPLANTATION: THE RECIPIENT 401
20.1 SELECTION AND WORKUP 401
Raja Kandaswamy, MD
20.2 SURGICAL PROCEDURES 403
Rainer W.G. Gruessner, MD
20.3 PERIOPERATIVE CARE, IMMUNOSUPPRESSIVE THERAPY, AND
POSTTRANSPLANT COMPLICATIONS 408
Raja Kandaswamy, MD
20.4 THE IDENTICAL TWIN TRANSPLANT EXPERIENCE: RECURRENCE OF
DISEASE 412
Rainer W.G. Gruessner, MD
CHAPTER 21 REGISTRY REPORT AND LONG-TERM OUTCOME 414
Angelika C. Gruessner, PhD
CHAPTER 22 ISLET AUTOTRANSPLANTATION AFTER PANCREATECTOMY: HISTORY AND OUTCOMES 419
David E.R. Sutherland, MD, PhD, Takashi Kobayashi, MD, Bernhard J. Hering, MD,
Tun Jie, MD, Annelisa M. Carlson, MD
CHAPTER 23 ISLET TRANSPLANTATION USING LIVING DONORS 429
Juliet Emamaullee, PhD, James Shapiro, MD, PhD
SECTION III LIVER TRANSPLANTATION
CHAPTER 24 PERSONAL REFLECTIONS AND HISTORY OF LIVING DONOR LIVER TRANSPLANTATION 438
Christoph E. Broelsch, MD, Silvio Nadalin, MD, Massimo Malagó, MD
CHAPTER 25 REGIONAL VARIATIONS IN THE U.S. LIVING DONOR EXPERIENCE 442
Mark Wang, MD, Irma Dixler, BSN, RN, Jonathan P. Fryer, MD
CHAPTER 26 INSTITUTIONAL NEEDS FOR LIVING DONOR: LIVER
TRANSPLANTATION 448
Alan J. Koffron, MD, Michael Abecassis, MD
CHAPTER 27 ROLE OF SPLIT LIVER TRANSPLANTATION FROM DECEASED DONORS: LESSONS LEARNED 453
Andrew M. Cameron, MD, PhD, Hasan Yersiz, MD, Ronald W. Busuttil, MD, PhD
CHAPTER 28 LIVER REGENERATION 459
Jeroen de Jonge, MD, PhD, Kim M. Olthoff, MD
CHAPTER 29 LIVING DONOR LIVER TRANSPLANTATION: THE DONOR 468
29.1 SELECTION AND WORKUP 468
Abhinav Humar, MD, Cheryl Jacobs, MS, LICSW, Ann Kalis, RN
29.2 ANESTHESIOLOGIC CONSIDERATIONS 475
Suzanne Shamsolkottabi, MD, Kumar G. Belani, MBBS, MS
29.3 SURGICAL PROCEDURES 477
29.4 PERIOPERATIVE CARE 500
Giuliano Testa, MD, Rose Luther-Campise, MD, Enrico Benedetti, MD
29.5 DONOR MORBIDITY AND MORTALITY 504
Dianne LaPointe Rudow, DrNP, Milan Kinkhabwala, MD, Jean C. Emond, MD
29.6 LONG-TERM DONOR OUTCOMES 513
James F. Trotter, MD, Jeff Campsen, MD, Igal Kam, MD
29.7 PSYCHOLOGICAL ASPECTS 518
Roshan Shrestha, MD
CHAPTER 30 LIVER TRANSPLANTATION: THE RECIPIENT 522
30.1 SELECTION AND WORKUP 522
Henkie P. Tan, MD, PhD, Thomas Shaw-Stiffel, MD, Kusum Tom, MD, Amadeo
Marcos, MD
30.2 ANESTHESIOLOGIC CONSIDERATIONS 526
Suzanne Shamsolkottabi, MD, Kumar G. Belani, MBBS, MS
30.3 SURGICAL PROCEDURES 533
30.4 OPTIMIZED VENOUS OUTFLOW 569
Giuliano Testa, MD, Enrico Benedetti, MD
30.5 ISCHEMIA AND REPERFUSION INJURY 572
Sei-ichiro Tsuchihashi, MD, PhD, Fady Kaldas, MD, Ronald W. Busuttil, MD, PhD,
Jerzy W. Kupiec-Weglinski, MD, PhD
30.6 SMALL-FOR-SIZE GRAFTS 576
Roberto Troisi, MD, PhD, Marleen Praet, MD, PhD, Bernard de Hemptinne MD, PhD
30.7 PERIOPERATIVE CARE OF THE LIVER RECIPIENT 583
Mark L. Sturdevant, MD, Ty Dunn, MD, Rainer W.G. Gruessner, MD
30.8 POSTTRANSPLANT COMPLICATIONS 589
Hiroyuki Furukawa, MD, Satoru Todo, MD
30.9 INTERVENTIONAL THERAPIES 601
Erik N.K. Cressman, MD, PhD
30.10 IMMUNOSUPPRESSIVE THERAPY 605
Roberto Gedaly, MD, Hosein Shokouh-Amiri, MD, Santiago R. Vera, MD, A. Osama
Gaber, MD
30.11 IMMUNOBIOLOGY 611
Kenneth J. Woodside, MD, John A. Daller, MD, PhD
30.12 CONTROVERSIAL INDICATIONS 617
30.13 DOMINO LIVER TRANSPLANTATION 635
30.14 LIVER RETRANSPLANTATION 643
30.15 LONG-TERM OUTCOME 651
30.16 STRATEGIES TO MAXIMIZE THE DONOR POOL 661
CHAPTER 31 LIVER TRANSPLANTATION: COST ANALYSIS 671
Mark W. Russo, MD, MPH, Robert S. Brown, MD, MPH
SECTION IV INTESTINAL TRANSPLANTATION
CHAPTER 32 HISTORY OF LIVING DONOR INTESTINAL TRANSPLANTATION 678
Rainer W.G. Gruessner, MD
CHAPTER 33 INTESTINAL TRANSPLANTATION – THE DONOR 685
33.1 SELECTION AND WORKUP 685
Enrico Benedetti, MD, Mark J. Holterman, MD, PhD, Giuliano Testa, MD
33.2 SURGICAL PROCEDURES AND PERIOPERATIVE CARE 688
Rainer W.G. Gruessner, MD
33.3 MORBIDITY, MORTALITY, LONG-TERM OUTCOME 690
Giuliano Testa, MD, Fabrizio Panaro, MD, Enrico Benedetti, MD
CHAPTER 34 INTESTINAL TRANSPLANTATION – THE RECIPIENT 694
34.1 SELECTION AND WORKUP 694
Enrico Benedetti, MD, Stefano DiDomenico, MD, Giuliano Testa, MD
34.2 SURGICAL PROCEDURES AND PERIOPERATIVE CARE 699
Rainer W.G. Gruessner, MD
34.3 IMMUNOSUPPRESSIVE THERAPY AND POSTOPERATIVE COMPLICATION 705
Enrico Benedetti, MD, Antonio Gangemi, MD, Giuliano Testa, MD
34.4 PATHOLOGY OF SMALL BOWEL TRANSPLANTATION 711
Jose Jessurun, MD, Stefan Pambuccian, MD
34.5 REGISTRY REPORT AND LONG-TERM OUTCOME 714
Shimul A. Shah, MD, David R. Grant, MD
34.6 INTESTINAL TRANSPLANTION: COST ANALYSIS 718
Giuliano Testa, MD, Aaron J. Simon, MHA, CHE, Enrico Benedetti, MD
PART IV: FUTURE DEVELOPMENTS AND ALTERNATIVES TO LIVING DONOR TRANSPLANTATION
CHAPTER 35 DUAL-ORGAN DONATION 723
Rainer W.G. Gruessner, MD
CHAPTER 36 USE OF LIVING DONORS FOR HIV-POSITIVE TRANSPLANT
CANDIDATES 725
Peter G. Stock, MD, PhD
CHAPTER 37 NEW IMMUNOSUPPRESSIVE PROTOCOLS 731
Rolf N. Barth, MD, Stuart J. Knechtle, MD
CHAPTER 38 STRATEGIES TO INDUCE TOLERANCE 737
Gregor Warnecke, MD, Kathryn J. Wood, Dphil
CHAPTER 39 XENOTRANSPLANTATION 748
Kazuhiko Yamada, MD, PhD, Prashanth Vallabhajosyula, MD, David H. Sachs, MD
CHAPTER 40 GENE THERAPY 760
Jonathan S. Bromberg, MD, Peter Boros, MD, Nan Zhang, PhD
CHAPTER 41 ORGANOGENESIS AND CLONING 769
Marilia Cascalho, MD, PhD, Brenda M. Ogle, PhD, Jeffrey L. Platt, MD
INDEX 773
Color plates appear between pages 418 and 419.
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