Organ Preservation for Transplantation Third Edition: Molecular Intelligence Unit
Buku diterbitkan Tahun 2010 oleh : Landes Bioscience, USA adalah buku Edisi Ketiga.
Judul: Organ Preservation for Transplantation Third Edition: Molecular Intelligence Unit
Pengarang: Luis H. Toledo-Pereyra
Penerbit: Landes Bioscience, USA
Tahun: 2010
Jumlah Halaman: 266 hal.
Author:
Luis H. Toledo-Pereyra Ahli Transplantasi Bedah, Peneliti dan Pendidik. Saat ini ia adalah Profesor Bedah dan Direktur Riset di Michigan State University, Kalamazoo Center dari Studi Kedokteran di mana ia mengajarkan mahasiswa kedokteran, warga dan rekan-rekan di inti medis dan penelitian bedah. Dia sangat tertarik dalam mempromosikan kegiatan ilmiah antara fakultas, warga dan mahasiswa kedokteran. Karyanya telah berkisar dari dasar pelestarian organ, mekanisme biologi molekul eriskemia dan reperfusi dan peran kemanusiaan medis pada perbaikan perawatan kesehatan.
Lingkup Pembahasan:
Buku ini mengemukakan transplantasi baru dan pelestarian spesialis dengan pendekatan bervariasi, pendekatan ini akan menyajikan pandangan dan alternatif yang berbeda dan pasti meningkatkan pengetahuan tentang bidang menantang yaitu pelestarian organ. Buku ini juga menunjukkan
penggambaran yang lebih akurat dari statusnya saat ini. Namun demikian, tujuan buku ini tetap persis sama seperti pada edisi pertama, yang "untuk menganalisis aspek yang paling penting dari pengadaan organ, perfusi dan pelestarian untuk transplantasi. "
Daftar Isi:
Foreword xiii
John S. Najarian
Prefac xv
Luis H. Toledo-Pereyra
1. Science of Organ Preservation 1
Roberto Anaya-Prado, Alexander H. Toledo, Juan M. Palma-Vargas and Luis H. Toledo-Pereyra
The Effects of Hypothermia 1
Hypothermia Works through Diff erent Mechanisms 1
Glycolytic Enzymes and Energy Stores 2
Calcium-Calmodulin Complex 3
Hipothermia-Induced Cell Swelling 6
Hypothermia and pH 8
The Effects of Preservation Solutions 8
Hypothermia and Microcirculation 10
Injury Caused by Preservation 10
Free Radicals and Preservation Injury 10
Endothelial Cell Adhesion Molecules and Preservation Injury 12
Th e Future of Organ Preservation 12
2. Organ Donation and Procurement 16
Francisco RodrÃguez-Quilantán, Alexander H. Toledo, Roberto Anaya-Prado and Luis H.
Toledo-Pereyra
Introduction 16
Criteria for Organ Donation: Brain Death 16
Non-Heart-Beating Organ Donors 16
Organ Donation and Procurement 17
Multivisceral Donation for Multivisceral Transplantation 30
Multivisceral Procurement for Multvisceral Transplantation 30
3. Perfusion and Storage Techniques 33
Amer Rajab, Ronald P. Pelletier and Mitchell L. Henry
Introduction 33
Goals of Preservation 33
Ischemic Phase 33
Organ Preservation and Injury 34
Organ Injury: Pathophysiology of Ischemic Phase 34
Organ Injury: Pathophysiology of Reperfusion Phase 35
Hypothermia 36
Cold Preservation 36
Preservation Solutions 37
Specific Preservation Solutions 39
Clinical Preservation 40
4. Organ Freezing 45
Luis H. Toledo-Pereyra, Fernando Lopez-Neblina and Alexander H. Toledo
Introduction 45
Difficulties of Organ Freezing 45
Kidney Freezing 46
Liver Freezing 49
Pancreas Freezing 49
Small Bowel Freezing 51
Heart Freezing .52
Freezing of Other Organs 53
5. Cellular and Molecular Biology of Ischemia Reperfusion 58
Shohachi Suzuki
Introduction .59
Cellular Mechanisms 59
Molecular Mechanisms in 63
Conclusion and Perspective 90
6. Metabolic Management 82
Sufan Chien
Ischemic Eff ects on Tissues and Organs 82
Metabolic Inhibition by Hypothermia 88
Inhibition of Tissue Metabolism by Hibernation 91
Metabolic Substrate Supplement 92
Other Pharmacologic Interventions 103
Preconditioning 107
Other Important Factors in Organ Preservation 107
Nature Still Provides the Best Preservation 108
Future Perspective 109
7. Kidney Preservation 124
Luis H. Toledo-Pereyra, Juan M. Palma-Vargas and Alexander H. Toledo
Introduction 124
Hypothermic Storage 124
Hypothermic Perfusion 128
Advantages and Disadvantages of Preservation Methods 131
Length of Preservation 134
Nonheartbeating Cadaveric Donors 135
Predicting Factors of Renal Function 136
Other Possibilities for Improved Kidney Preservation 137
8. Pancreas Preservation 143
Shinichi Matsumoto, Hirofumi Noguchi, Naoya Kobayashi, Angelika Gruessner and David
E.R. Sutherland
History of Pancreas Preservation 143
Clinical Pancreas Transplant Results 145
Current Advances in Pancreas Preservation 145
Pancreas Preservation before Islet Isolation and Transplantation 146
9. Liver Preservation 153
James V. Guarrera
Introduction 153
Management of the Brain Dead Donor 154
Procurement Techniques 156
Liver Reperfusion and Preservation Injury 157
Clinical Implications of Reperfusion/Preservation Injury 157
Extended Criteria Donors: Characteristics Th at Are Synergistic with Preservation Injury 160
Elderly Donors 160
Underlying Liver Histopathology: Steatosis 161
Length of Cold Ischemia Time 161
Ischemia Associated with Liver Injury: Donation aft er Cardiac Death 162
Clinically Available Preservation Solutions 162
Comparison of UW, HTK and Celsior in Deceased Donor Liver Transplantation 164
Comparison of UW and HTK in Living Donor Transplantation 165
Pharmacologic Treatment of the Donor 165
Novel Liver Preservation Strategies 165
Apoptosis Inhibitors 165
Nitric Oxide Donors 166
Pentoxifylline 166
Antioxidants and Heat-Shock Proteins 166
IGL-1: Na+/K+ Inversion and PEG Substitution 167
Polysol 167
Vasosol 167
Selective Matrix Metalloproteinase Inhibitors 167
Hibernation: Intrinsic Protection from Ischemia-Reperfusion Injury 168
Ischemic Preconditioning of Liver Grafts 168
Machine Perfusion as a Liver Preservation Strategy 168
Hypothermic Machine Perfusion and Marginal Livers 168
The Columbia Hypothermic Machine Perfusion Clinical Trial 169
10. Small Bowel Preservation 175
Debra McKeehen, Luis H. Toledo-Pereyra and Roberta E. Sonnino
Introduction 175
Historical Background 175
Assessment of Absorptive Capacity aft er Preservation 176
Role of Endotoxin and Bacteria in Preserved Small Bowel 177
Attempts at Clinical Preservation 177
Prevention and Amelioration of Ischemia-Reperfusion Injury 177
Use of Immunosuppressive Drugs for Graft Pretreatment 178
Search for Improved Preservation Solutions 178
Intraluminal Hypothermic Perfusion 179
Effects of Donor Nutritional Status 180
Reduction of Oxidative and Energetic Stress 180
Recent Research Work Using Human Small Bowel 180
Clinical Small Bowel Preservation—Current Status 181
11. Heart Preservation 185
Yoshikazu Suzuki and Francis D. Pagani
Introduction 185
Background 185
Time Limitations with Heart Preservation 186
Limitations in the Availability of Cardiac Allograft s 186
Donor Management Strategies before Procurement: Signifi cant Impact of Brain Death on the
Outcome of Heart Transplantation 186
Evolving Concepts of the Association of Brain Death with Acute Allograft Rejection and
Chronic Allograft Vasculopathy 187
Ischemia-Reperfusion Injury, Infl ammatory Response and Chronic CAV: Central Role of
Endothelial Dysfunction 188
Microvasculature Prothrombogenicity in the Pathophisiology of Cardiac Allograft
Vasculopathy 189
Methods of Myocardial Preservation 190
Ischemic Hypothermic Storage 190
Hypothermia 191
Cardioplegia and Composition of Preservation Solutions 191
Pharmacologic Modifi cations to Cardioplegic Solutions: Attenuating Ischemia-Reperfusion
Injury during Myocardial Preservation 193
Myocardial Cellular Protection from “Stone Heart” (Cardiomyocyte Hypercontracture):
Irreversible Ischemia-Reperfusion Injury 198
Alternative Strategies to Hypothermic Ischemic Storage 203
12. Heart and Lung Preservation 214
Jason A. Williams, Ashish S. Shah and William A. Baumgartner
Introduction 214
Donor Organ Injury 215
Heart-Lung and Lung Preservation Techniques 218
Composition of Perfusate and Storage Solutions 221
Lung Inflation during Storage 227
Preservation during Implantation 227
Reperfusion Modifi cation 227
13. Future of Organ Procurement and Preservation 239
Luis H. Toledo-Pereyra
Index 243
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