Molecular Genetics of Recombination
Buku ini diterbitkan pada tahun 2007 oleh Springer-Verlag Berlin Heidelberg adalah buku edisi Pertama..
Judul: Molecular Genetics of Recombination
Oleh: Andrés Aguilera • Rodney Rothstein (Editor)
Penerbit: Springer-Verlag Berlin Heidelberg
Tahun: 2007
Jumlah Halaman: 536 hal.
Editor:
Professor Dr. Andrés Aguilera
Centro Andaluz de Biologia Molecular
y Medicina Regenerativa CABIMER
CSIC-Universidad de Sevilla
Av. Américo Vespucio s/n
41092 Sevilla
Spain
Professor Dr. Rodney Rothstein
Department of Genetics & Development
Columbia University Medical Center
701West 168th Street, HHSC 1608
New York, NY 10032-2704
USA
Lingkup Pembahasan:
Buku ini disusun dengan 17 bab yang ditulis oleh para peneliti yang berkualitas pada setiap topik. Bab-bab mencakup rekombinasi genetik dari sejarah dan perspektif konseptual. Setiap bab berisi pengenalan mendalam dan up-to-date serta analisis keadaan saat ini tentang pengetahuan subjek.
Selain itu, bab yang dikandung dan ditulis secara mandiri, sehingga mereka dapat dibaca secara independen pada masing-masing Bab,.
Daftar Isi:
Genetics of recombination in the model bacterium Escherichia coli 1
Bénédicte Michel, Zeynep Baharoglu, and Roxane Lestini
Abstract 1
1 Introduction 1
2 Genes and pathways 2
3 The repair of DNA lesions 8
4 Recombination and replication. 11
Acknowledgments. 18
References .18
Homologous recombination in low dC + dG Gram-positive bacteria 27
Humberto Sanchez, Begoña Carrasco, Silvia Ayora, and Juan C. Alonso
Abstract 27
1 Proteins required for recombinational repair 27
2 Recombination avenues. .34
3 Horizontal gene transfer .39
4 Fate of the incoming DNA 40
5 Barriers for HGT 46
Acknowledgements .46
References 46
The bacterial RecA protein: structure, function, and regulation 53
Michael M. Cox
Abstract 53
1 The role of recombination in DNA metabolism 53
2 The RecA protein of Escherichia coli 54
3 Regulation of RecA function 65
4 Regulation summary 76
References 77
Biochemistry of eukaryotic homologous recombination 95
Wolf-Dietrich Heyer
Abstract 95
1 Introduction 95
2 Homologous recombination in different contexts 97
3 Biochemistry of recombination proteins 98
4 Regulation of recombination 119
5 Conclusion 122
Acknowledgements 123
References. 123
DNA helicases in recombination 135
Hannah L. Klein
Abstract 135
1 Recombination pathways and models 135
2 DNA helicases in mitotic recombination 140
3 DNA helicases in meiotic recombination 149
4 Replication and repair helicases 152
5 Conclusions 155
Acknowledgements 156
References .156
Holliday junction resolution 169
Matthew C. Whitby
Abstract 169
1 A brief overview of HJ formation and processing 169
2. The HJ resolvases 172
3 Mus81 182
4 Future perspectives 190
Acknowledgements 191
References .191
Replication forks and replication checkpoints in repair 201
Dana Branzei and Marco Foiani
Abstract 201
1 DNA replication, checkpoint proteins, and chromosome integrity ........ 201
2 Stalled versus collapsed replication forks and fork stabilization versus fork restart 202
3 Sensing stalled forks and checkpoint mediated stabilization of stalled forks 203
4 Replication fork restart and repair mechanisms 205
5 Coordination between DNA replication, topology, and chromatin
Structure 211
Acknowledgements 213
References 213
Sister chromatid recombination 221
Felipe Cortés-Ledesma, Félix Prado and Andrés Aguilera
Abstract 221
1 Introduction 221
2 Homologous recombination: a mechanism with major activity during replication 222
3 Methods for the measurement of sister-chromatid recombination 26
4 DNA repair genes required for SCR 230
5 Specific functions required for SCR 235
6 Concluding remarks 240
Acknowledgements 241
References 241
Mating-type switching in S. pombe 251
Benoit Arcangioli, Laura Roseaulin, and Allyson Holmes
Abstract 251
1 Fission yeast life cycle 251
2 The pattern of switching. .252
3 The mating-type region 253
4 A site- and strand-specific imprint at mat1 254
5 Cis-acting elements controlling the imprint .257
6 Trans-acting swi (switch) genes 257
7 The direction of replication model 263
8 Imprinting formation is coupled to DNA replication 264
9 Imprinting protection 267
10 Mating-type switching 267
11 Mus81 is the essential nuclease resolving sister chromatid Recombination 272
12 Outlook and future directions. 273
Acknowledgements 275
References 275
Multiple mechanisms of repairing meganuclease-induced double-strand DNA
breaks in budding yeast 285
James E. Haber
Abstract 285
1 Introduction 285
2 MAT switching in Saccharomyces, a paradigm for DSB repair 286
3 HO and I-SceI-induced ectopic gene conversions and the control of reciprocal
crossing-over 291
4 Single-strand annealing (SSA) .297
5 Break-induced replication (BIR) 299
6 Nonhomologous end-joining (NHEJ) 305
7 Future prospects 308
Acknowledgements 308
References 308
The cell biology of mitotic recombination in Saccharomyces cerevisiae 317
Michael Lisby and Rodney Rothstein
Abstract 317
1 Choreography of DNA double-strand break repair 317
2 Cell cycle regulation of recombination foci 321
3 The cellular response to stalled and collapsed DNA replication forks. 322
4 Spontaneous foci 324
5 Dynamics of proteins in foci 324
6 Centers of recombinational DNA repair 325
7 Nucleolar exclusion of homologous recombination 326
8 Cohesins 326
9 Molecular switches. 326
10 Future perspectives. 327
References 328
The cell biology of homologous recombination 335
Sheba Agarwal, Roland Kanaar, and Jeroen Essers.
Abstract 335
1 Introduction 335
2 Cell biological analyses of homologous recombination proteins 336
3 Controlled induction of DNA damage 337
4 Homologous recombination pathways 340
5 Recombination and replication. 348
6 The function of DNA damage induced foci 349
References. 351
BRCA2: safeguarding the genome through homologous recombination 363
Nicole Christ, Mary Ellen Moynahan, Maria Jasin
Abstract 363
1 Introduction 363
2 BRCA2: a tumor suppressor with diverse domain structures in different organisms. 364
3 Binding Partners of BRCA2. 366
4 BRCA2 and homologous recombination. 368
5 BRCA2 is essential for development but dispensable for the survival of cancer cells .370
6 Conclusions 373
Acknowledgments 373
References 374
Meiotic recombination 381
Neil Hunter
Abstract .381
1 Overview 381
2 Meiosis 381
3 Overview of meiotic recombination. 385
4 Initiation of meiotic recombination 387
5 Homolog pairing and formation of joint molecules 400
6 Interhomolog bias. 408
7 Crossover control 412
8 Closing remarks. 421
Acknowledgements 422
References 422
Site-specific recombination 443
Ian Grainge and David J. Sherratt.
Abstract 443
1 Introduction 443
2 The two families of recombinases: tyrosine and serine 445
3 The tyrosine recombinase family 446
4 Serine family recombinases 451
6 Applications of site-specific recombination 456
7 Related proteins 457
8 Concluding remarks 462
References 463
V(D)J recombination: mechanism and consequences 469
Martin Gellert
Abstract 469
1 Introduction 469
2 General properties of V(D)J recombination 470
3 The RAG genes and proteins 472
4 End processing and joining in V(D)J recombination 480
References 482
Nonhomologous end-joining: mechanisms, conservation and relationship to illegitimate recombination 487
Thomas E. Wilson .
Abstract . .487
1 Introduction 487
2 DNA mechanisms of nonhomologous end-joining .488
3 Protein pathways for nonhomologous end-joining. 491
4 Species conservation of Ku-dependent NHEJ .497
5 NHEJ interplay with host cell processes 502
6 Outcomes of NHEJ and its deficiency .504
7 Concluding remarks .505
References 505
Abbreviations 512
Index 515
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