Friday, March 4, 2016

Molecular Genetics of Recombination






Molecular Genetics of Recombination
Buku ini diterbitkan pada tahun 2007  oleh  Springer-Verlag Berlin Heidelberg  adalah buku edisi Pertama..



Judul:   Molecular Genetics of Recombination
Oleh:   Andrés Aguilera • Rodney Rothstein (Editor)
Penerbit:   Springer-Verlag Berlin Heidelberg
Tahun: 2007
Jumlah Halaman:  536 hal.

Editor:

Professor Dr. Andrés Aguilera
Centro Andaluz de Biologia Molecular
y Medicina Regenerativa CABIMER
CSIC-Universidad de Sevilla
Av. Américo Vespucio s/n
41092 Sevilla
Spain
Professor Dr. Rodney Rothstein
Department of Genetics & Development
Columbia University Medical Center
701West 168th Street, HHSC 1608
New York, NY 10032-2704
USA

Lingkup Pembahasan:
Buku ini disusun dengan 17 bab yang ditulis oleh  para peneliti yang berkualitas pada setiap topik. Bab-bab mencakup rekombinasi genetik dari sejarah dan perspektif konseptual. Setiap bab berisi pengenalan mendalam dan up-to-date serta analisis keadaan saat ini  tentang pengetahuan  subjek.
Selain itu, bab yang dikandung dan ditulis secara mandiri, sehingga mereka dapat dibaca secara independen pada masing-masing Bab,.

Daftar Isi:

Genetics of recombination in the model bacterium Escherichia coli   1
Bénédicte Michel, Zeynep Baharoglu, and Roxane Lestini 
    Abstract   1
    1     Introduction   1
    2     Genes and pathways  2
    3     The repair of DNA lesions   8
    4     Recombination and replication.  11
    Acknowledgments. 18
    References .18
Homologous recombination in low dC + dG Gram-positive bacteria  27
Humberto Sanchez, Begoña Carrasco, Silvia Ayora, and Juan C. Alonso 
    Abstract   27
    1     Proteins required for recombinational repair   27
    2     Recombination avenues.  .34
    3     Horizontal gene transfer  .39
    4     Fate of the incoming DNA 40
    5     Barriers for HGT   46
    Acknowledgements .46
    References  46
The bacterial RecA protein: structure, function, and regulation  53
Michael M. Cox
    Abstract   53
    1     The role of recombination in DNA metabolism 53
    2     The RecA protein of Escherichia coli  54
    3     Regulation of RecA function  65
    4     Regulation summary  76
    References  77
Biochemistry of eukaryotic homologous recombination  95
Wolf-Dietrich Heyer 
    Abstract   95
    1     Introduction  95
    2     Homologous recombination in different contexts  97
    3     Biochemistry of recombination proteins  98
    4     Regulation of recombination   119
    5     Conclusion   122
    Acknowledgements 123
    References. 123
DNA helicases in recombination  135
Hannah L. Klein 
    Abstract   135
    1     Recombination pathways and models   135
    2     DNA helicases in mitotic recombination   140
    3     DNA helicases in meiotic recombination  149
    4     Replication and repair helicases   152
    5     Conclusions  155
    Acknowledgements  156
    References .156
Holliday junction resolution  169
Matthew C. Whitby 
    Abstract   169
    1     A brief overview of HJ formation and processing   169
    2.     The HJ resolvases   172
    3     Mus81  182
    4     Future perspectives  190
    Acknowledgements  191
    References .191
Replication forks and replication checkpoints in repair  201
Dana Branzei and Marco Foiani 
    Abstract   201
    1     DNA replication, checkpoint proteins, and chromosome integrity ........ 201
    2     Stalled versus collapsed replication forks and fork stabilization versus fork restart  202
    3     Sensing stalled forks and checkpoint mediated stabilization of stalled forks   203
    4     Replication fork restart and repair mechanisms   205
    5     Coordination between DNA replication, topology, and chromatin
    Structure   211
    Acknowledgements  213
    References  213
Sister chromatid recombination  221
Felipe Cortés-Ledesma, Félix Prado and Andrés Aguilera 
    Abstract  221
    1     Introduction  221
    2     Homologous recombination: a mechanism with major activity during replication  222
    3     Methods for the measurement of sister-chromatid recombination   26
    4     DNA repair genes required for SCR   230
    5     Specific functions required for SCR   235
    6     Concluding remarks   240
    Acknowledgements 241
    References  241
Mating-type switching in S. pombe  251
Benoit Arcangioli, Laura Roseaulin, and Allyson Holmes 
    Abstract  251
    1     Fission yeast life cycle   251
    2     The pattern of switching. .252
    3     The mating-type region   253
    4     A site- and strand-specific imprint at mat1  254
    5     Cis-acting elements controlling the imprint .257
    6     Trans-acting swi (switch) genes  257
    7     The direction of replication model  263
    8     Imprinting formation is coupled to DNA replication  264
    9     Imprinting protection  267
    10     Mating-type switching   267
    11     Mus81 is the essential nuclease resolving sister chromatid  Recombination  272
    12     Outlook and future directions.  273
    Acknowledgements  275
    References  275
Multiple mechanisms of repairing meganuclease-induced double-strand DNA
breaks in budding yeast  285

James E. Haber 
    Abstract   285
    1     Introduction   285
    2     MAT switching in Saccharomyces, a paradigm for DSB repair  286
    3     HO and I-SceI-induced ectopic gene conversions and the control of reciprocal
           crossing-over    291
    4     Single-strand annealing (SSA)  .297
    5     Break-induced replication (BIR)  299
    6     Nonhomologous end-joining (NHEJ)  305
    7     Future prospects  308
    Acknowledgements  308
    References 308
The cell biology of mitotic recombination in Saccharomyces cerevisiae 317
Michael Lisby and Rodney Rothstein 
    Abstract   317
    1     Choreography of DNA double-strand break repair  317
    2     Cell cycle regulation of recombination foci   321
    3     The cellular response to stalled and collapsed DNA replication forks. 322
    4     Spontaneous foci   324
    5     Dynamics of proteins in foci   324
    6     Centers of recombinational DNA repair 325
    7     Nucleolar exclusion of homologous recombination  326
    8     Cohesins   326
    9     Molecular switches.  326
    10     Future perspectives.  327
    References  328
The cell biology of homologous recombination  335
Sheba Agarwal, Roland Kanaar, and Jeroen Essers.
    Abstract  335
    1     Introduction  335
    2     Cell biological analyses of homologous recombination proteins  336
    3     Controlled induction of DNA damage   337
    4     Homologous recombination pathways   340
    5     Recombination and replication.  348
    6     The function of DNA damage induced foci  349
    References.  351
BRCA2: safeguarding the genome through homologous recombination  363
Nicole Christ, Mary Ellen Moynahan, Maria Jasin  
    Abstract  363
    1     Introduction   363
    2     BRCA2: a tumor suppressor with diverse domain structures in different organisms.  364
    3     Binding Partners of BRCA2. 366
    4     BRCA2 and homologous recombination.  368
    5     BRCA2 is essential for development but dispensable for the survival of cancer cells .370
    6     Conclusions   373
    Acknowledgments  373
    References  374
Meiotic recombination  381
Neil Hunter  
    Abstract .381
    1     Overview  381
    2     Meiosis   381
    3     Overview of meiotic recombination.  385
    4     Initiation of meiotic recombination  387
    5     Homolog pairing and formation of joint molecules   400
    6     Interhomolog bias.  408
    7     Crossover control  412
    8     Closing remarks.  421
    Acknowledgements  422
    References  422
Site-specific recombination  443
Ian Grainge and David J. Sherratt. 
    Abstract   443
    1     Introduction  443
    2     The two families of recombinases: tyrosine and serine 445
    3     The tyrosine recombinase family  446
    4     Serine family recombinases   451
    6     Applications of site-specific recombination  456
    7     Related proteins  457
    8     Concluding remarks  462
    References   463
V(D)J recombination: mechanism and consequences  469
Martin Gellert 
Abstract  469
    1     Introduction  469
    2     General properties of V(D)J recombination   470
    3     The RAG genes and proteins  472
    4     End processing and joining in V(D)J recombination  480
    References 482
Nonhomologous end-joining: mechanisms, conservation and relationship to illegitimate recombination 487
Thomas E. Wilson .
    Abstract . .487
    1     Introduction   487
    2     DNA mechanisms of nonhomologous end-joining .488
    3     Protein pathways for nonhomologous end-joining.  491
    4     Species conservation of Ku-dependent NHEJ  .497
    5     NHEJ interplay with host cell processes   502
    6     Outcomes of NHEJ and its deficiency  .504
    7     Concluding remarks  .505
    References  505
Abbreviations   512
Index   515


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